Scaparvin A, A Novel Caged cis-Clerodane with an Unprecedented C-6/C-11 Bond, and Related Diterpenoids from the Liverwort Scapania parva
Scaparvin A, A Novel Caged cis-Clerodane with an Unprecedented C-6/C-11 Bond, and Related Diterpenoids from the Liverwort Scapania parva
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Scaparvin A，一种新型笼状顺式 Clerodane，具有前所未有的 C-6/C-11 键，以及来自小叶地钱草的相关二萜类化合物
DOI：
10.1021/ol1019458
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发表时间：
2010-10-01
期刊：
影响因子：
5.2
通讯作者：
Lou, Hong-Xiang
中科院分区：
文献类型：
--
作者：
Guo, Dong-Xiao;Zhu, Rong-Xiu;Lou, Hong-Xiang
从中国苔草中分离得到一种新型笼状顺式氯烷二萜 scaparvin A，它具有前所未有的 C-6/C-11 键和缩酮环，以及四种新的顺式氯烷衍生物 scaparvins B-E。通过分析 NMR 和 CD 数据以及电子圆二色性 (ECD) 计算，阐明了它们的绝对结构。有人提出酶促分子内羟醛反应是 scaparvin A 生物遗传途径的关键步骤。
A novel caged cis-clerodane diterpenoid, scaparvin A, possessing an unprecedented C-6/C-11 bond and a ketal ring, as well as four new cis-clerodane derivatives, scaparvins B-E, were isolated from the Chinese liverwort Scapania parva. Their absolute structures were elucidated by analysis of NMR and CD data coupled with electronic circular dichroism (ECD) calculations. It was proposed that an enzymatic intramolecular aldol reaction was the key step in the biogenetic pathway of scaparvin A.