Large-scale DNA methylation expression analysis across 12 solid cancers reveals hypermethylation in the calcium-signaling pathway.
Large-scale DNA methylation expression analysis across 12 solid cancers reveals hypermethylation in the calcium-signaling pathway.
复制标题
对 12 种实体癌的大规模 DNA 甲基化表达分析揭示了钙信号通路中的高甲基化
DOI：
10.18632/oncotarget.14417
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发表时间：
2017-02-14
期刊：
影响因子：
--
通讯作者：
Kong QP
中科院分区：
文献类型：
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作者：
Wang XX;Xiao FH;Li QG;Liu J;He YH;Kong QP
肿瘤发生与DNA甲基化在基因表达调控中的作用有关。然而，癌症是一种高度异质性的疾病，其中DNA甲基化和基因表达的全球模式，特别是在不同的癌症中，还没有得到很好的理解。我们研究了DNA甲基化状态及其与癌症基因组图谱中12种实体癌类型基因表达的相关性。结果显示，整体超甲基化是所有12种癌症类型的重要特征。此外，在癌症中，表观遗传沉默的基因比表观遗传激活的基因更多。进一步的分析确定了在不同癌症类型的钙信号通路中共有的表观遗传沉默基因。逆转钙信号通路相关基因的异常DNA甲基化可能是抑制癌症和开发抗癌药物的有效策略。
Tumorigenesis is linked to the role of DNA methylation in gene expression regulation. Yet, cancer is a highly heterogeneous disease in which the global pattern of DNA methylation and gene expression, especially across diverse cancers, is not well understood. We investigated DNA methylation status and its association with gene expressions across 12 solid cancer types obtained from The Cancer Genome Atlas. Results showed that global hypermethylation was an important characteristic across all 12 cancer types. Moreover, there were more epigenetically silenced than epigenetically activated genes across the cancers. Further analysis identified epigenetically silenced genes shared in the calcium-signaling pathway across the different cancer types. Reversing the aberrant DNA methylation of genes involved in the calcium-signaling pathway could be an effective strategy for suppressing cancers and developing anti-cancer drugs.