Novel roles for the MiTF/TFE family of transcription factors in organelle biogenesis, nutrient sensing, and energy homeostasis.
Novel roles for the MiTF/TFE family of transcription factors in organelle biogenesis, nutrient sensing, and energy homeostasis.
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DOI：
10.1007/s00018-014-1565-8
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发表时间：
2014-07
影响因子：
8
通讯作者：
Puertollano, Rosa
中科院分区：
文献类型：
--
作者：
Martina, Jose A.;Diab, Heba I.;Li, Huiqing;Puertollano, Rosa
基本螺旋-环-螺旋亮氨酸拉链转录因子的 MiTF/TFE 家族包括 MITF、TFEB、TFE3 和 TFEC。一些家族成员参与特定细胞类型（如肥大细胞、破骨细胞和黑素细胞）的发育和增殖已得到充分证实。值得注意的是，最近的证据表明 MiTF/TFE 家族在细胞器生物发生、营养传感和能量代谢中发挥着关键作用。 MiTF/TFE 家族也与人类疾病有关。大多数 MiTF/TFE 家族成员的突变或异常表达与不同类型的癌症有关。与此同时，它们最近已成为治疗神经系统和溶酶体疾病的新颖且非常有前途的靶标。这个令人着迷的转录因子家族的特征极大地扩展了我们对细胞如何使环境信号（例如营养可用性）与基因表达、能量产生和细胞稳态同步的理解。
The MiTF/TFE family of basic helix-loop-helix leucine zipper transcription factors includes MITF, TFEB, TFE3, and TFEC. The involvement of some family members in the development and proliferation of specific cell types, such as mast cells, osteoclasts, and melanocytes is well established. Notably, recent evidence suggests that the MiTF/TFE family plays a critical role in organelle biogenesis, nutrient sensing, and energy metabolism. The MiTF/TFE family is also implicated in human disease. Mutations or aberrant expression of most MiTF/TFE family members has been linked to different types of cancer. At the same time, they have recently emerged as novel and very promising targets for the treatment of neurological and lysosomal diseases. The characterization of this fascinating family of transcription factors is greatly expanding our understanding of how cells synchronize environmental signals, such as nutrient availability, with gene expression, energy production, and cellular homeostasis.
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影响因子：
64.8
作者：
Bertolotto, Corine;Lesueur, Fabienne;Bressac-de Paillerets, Brigitte
通讯作者：
Bressac-de Paillerets, Brigitte
DOI：
10.1073/pnas.0931430100
发表时间：
2003-05-13
影响因子：
11.1
作者：
Davis, IJ;Hsi, BL;Fisher, DE
通讯作者：
Fisher, DE
DOI：
10.1073/pnas.1305623110
发表时间：
2013-05-07
影响因子：
11.1
作者：
Decressac, Mickael;Mattsson, Bengt;Bjorklund, Anders
通讯作者：
Bjorklund, Anders
影响因子：
64.8
作者：
Carreira, S;Goodall, J;Goding, CR
通讯作者：
Goding, CR
影响因子：
5.3
作者：
Bellot, Gregory;Garcia-Medina, Raquel;Mazure, Nathalie M.
通讯作者：
Mazure, Nathalie M.