Anteroposterior patterning in adult abdominal segments of Drosophila
Anteroposterior patterning in adult abdominal segments of Drosophila
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DOI：
10.1006/dbio.2001.0529
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发表时间：
2002-02-01
影响因子：
2.7
通讯作者：
Duncan, I
中科院分区：
文献类型：
--
作者：
Kopp, A;Duncan, I
果蝇成虫腹部的角质层是由成骨组织细胞巢形成的，在变态过程中，成体组织母细胞会增殖和迁移，以取代多倍体幼虫的表皮细胞。在这份报告中，我们提出了四个关键的模式基因的表达，增强(EN)，刺猬(HH)，补丁(PTC)，和视神经失明(OMB)，在羽化后的第一个42小时，这一时期的成年模式建立。此外，我们还描述了同源异型基因Ultrabithorax、BUBLAR-A和BURBAL-B的表达，这些基因决定了成人腹部节段的命运。我们的结果表明，在早期的蛹阶段，腹部节段彼此独立地发育，并且一些模式事件独立于HH、无翼和十肢瘫痪信号。我们表明，在节段的大部分前部的模式和极性是在没有来自HH的输入的情况下指定的，并提出了腹部虎类具有潜在的对称模式的证据，在该对称模式上叠加了HH的模式。造成这种潜在对称性的信号仍有待确定。(C)2002年爱思唯尔科学公司。
The cuticle of the adult abdomen of Drosophila is produced by nests of imaginal histoblasts, which proliferate and migrate during metamorphosis to replace the polyploid larval epidermal cells. In this report, we present a detailed description of the expression of four key patterning genes, engrailed (en), hedgehog (hh), patched (ptc), and optomotor-blind (omb), in abdominal histoblasts during the first 42 h after pupariation, a period in which the adult pattern is established. In addition, we describe the expression of the homeotic genes Ultrabithorax, abdominal-A, and Abdominal-B, which specify the fates of adult abdominal segments. Our results indicate that abdominal segments develop in isolation from one another during early pupal stages, and that some patterning events are independent of hh, wingless, and decapentaplegic signaling. We show that pattern and polarity in a large anterior portion of the segment are specified without input from Hh, and present evidence that abdominal tergites possess an underlying symmetric pattern upon which patterning by Hh is superimposed. The signals responsible for this underlying symmetry remain to be identified. (C) 2002 Elsevier Science.