COOH-terminal decamers in proteins are non-random
COOH-terminal decamers in proteins are non-random
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DOI：
10.1016/s0014-5793(97)00112-9
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发表时间：
1997-03-10
期刊：
影响因子：
3.5
通讯作者：
Kisselev, L
中科院分区：
文献类型：
--
作者：
Berezovsky, IN;Kilosanidze, GT;Kisselev, L
我们对蛋白质羧基端（C）氨基酸序列进行了详尽的统计分析。C端十肽的组成与蛋白质总氨基酸组成的预期不同。coli、酵母菌和H.在智人中，显示带正电荷的氨基酸残基过多，而Gly残基不足。C-末端偏向性是蛋白质结构的一个新特征，在涉及分子进化、空间结构、翻译终止和蛋白质折叠时，应考虑C-末端偏向性，（C）1997 Federation of European Biochemical Societies.
We have undertaken an exhaustive statistical analysis of the amino acid sequences at the carboxyl-terminal (C) ends of proteins, The composition of the C-terminal decapeptides differs from that expected for the given proteins from the overall amino acid composition, For E. coli, yeast, and H. sapiens it was shown that positively charged amino acid residues are over-represented while Gly residues are under-represented. The C-terminal bias, a novel feature of protein structure, should be taken into account when molecular evolution, spatial structure, translational termination and protein folding are concerned, (C) 1997 Federation of European Biochemical Societies.