Reactivation of Human Herpes Virus-6 in the Renal Tissue of a Patient with Drug-induced Hypersensitivity Syndrome/Drug Rash with Eosinophilia and Systemic Symptoms (DIHS/DRESS)
Reactivation of Human Herpes Virus-6 in the Renal Tissue of a Patient with Drug-induced Hypersensitivity Syndrome/Drug Rash with Eosinophilia and Systemic Symptoms (DIHS/DRESS)
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DOI：
10.2169/internalmedicine.55.6287
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发表时间：
2016-01-01
影响因子：
1.2
通讯作者：
Otsuka, Fumio
中科院分区：
文献类型：
--
作者：
Hagiya, Hideharu;Iwamuro, Masaya;Otsuka, Fumio
一名74岁男性，服用甲氧苄啶-磺胺甲恶唑3周后出现药物性超敏反应综合征/药疹伴嗜酸性粒细胞增多和全身症状（DIHS/DRESS）。在临床过程的早期阶段，他出现了肾功能不全。肾活检显示肉芽肿性肾小管间质性肾炎伴肾小管上皮细胞中人类疱疹病毒（HHV）-6增殖。经皮质类固醇治疗后，全身皮疹及肾功能逐渐改善。本例患者是第二例DIHS/DRESS患者，证实了肾组织中HHV-6的可能再活化。病毒再激活在DIHS/DRESS中的临床作用必须进一步阐明。
A 74-year-old man who had been administered trimethoprim-sulfamethoxazole for three weeks suffered from drug-induced hypersensitivity syndrome/drug rash with eosinophilia and systemic symptoms (DIHS/DRESS). In the early stage of the clinical course, he developed renal dysfunction. A renal biopsy showed granulomatous tubulointerstitial nephritis accompanying the proliferation of human herpes virus ( HHV)-6 in tubular epithelial cells. With corticosteroid therapy, the systemic rash and renal function gradually improved. The present patient is the second case of DIHS/DRESS demonstrating a possible reactivation of HHV-6 in the renal tissue. The clinical role of viral reactivation in DIHS/DRESS must be further elucidated.