Cognitive Changes during Prolonged Stay at High Altitude and Its Correlation with C-Reactive Protein.
Cognitive Changes during Prolonged Stay at High Altitude and Its Correlation with C-Reactive Protein.
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长期高海拔认知变化及其与C反应蛋白的相关性
DOI：
10.1371/journal.pone.0146290
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发表时间：
2016
期刊：
影响因子：
3.7
通讯作者：
Feng H
中科院分区：
文献类型：
--
作者：
Hu SL;Xiong W;Dai ZQ;Zhao HL;Feng H
超敏C反应蛋白(HsCRP)可能是阿尔茨海默病(AD)、中风和血管性痴呆引起的认知损害的危险因素。本研究探讨外周血hsCRP水平与高原暴露所致认知功能减退的相关性。这项研究是对100名从未到过高原的男性军事参与者进行的。分别在海拔500m、海拔3650m、进营后3d、1个月、3个月及返回海拔500m后1个月、1个月、3个月进行脑血氧饱和度监测、事件相关电位(P300、N200)检测及神经认知功能评定，并测定血清总hsCRP、IL-6、Hcy水平。高原使脑血氧饱和度增加，P300和N200潜伏期延长，认知功能受损，血浆hsCRP水平升高。但在到达大本营(4400米)后1个月和3个月时，他们都有不同程度的恢复。P300潜伏期和hsCRP水平与认知成绩密切相关。这些结果提示，认知功能减退发生在高海拔地区的急性期，在长时间进入高海拔地区后，可能由于习服而恢复。血浆hsCRP与神经认知功能呈负相关，可能成为预测高原认知功能障碍的潜在生物标志物。
Hypersensitive C-reaction protein (hsCRP) may be a risk factor for cognitive impairment resulting from Alzheimer’s disease (AD), stroke, and vascular dementia. This study explored the correlation of peripheral blood hsCRP level with cognitive decline due to high altitude exposure. The study was conducted on 100 male military participants who had never been to high altitude. Cerebral oxygen saturation monitoring, event related potentials (P300, N200) detection, and neurocognitive assessment was performed and total hsCRP, interleukin-6 (IL-6), and homocysteine was estimated at 500m altitude, 3650m altitude, 3day, 1, and 3 month post arriving at the base camp (4400m), and 1 month after coming back to the 500m altitude. High altitude increased brain oxygen saturation, prolonged P300 and N200 latencies, injured cognitive functions, and raised plasma hsCRP levels. But they all recovered in varying degrees at 1 and 3 month post arriving at the base camp (4400m). P300 latencies and hsCRP levels were strongly correlated to cognitive performances. These results suggested that cognitive deterioration occurred during the acute period of exposure to high altitude and may recover probably owning to acclimatization after extended stay at high altitude. Plasma hsCRP is inversely correlated to neurological cognition and it may be a potential biomarker for the prediction of high altitude induced cognitive dysfunction.