Feed your head: neurodevelopmental control of feeding and metabolism.
Feed your head: neurodevelopmental control of feeding and metabolism.
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DOI：
10.1146/annurev-physiol-021113-170347
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发表时间：
2014
影响因子：
18.2
通讯作者：
Blackshaw S
中科院分区：
文献类型：
--
作者：
Lee DA;Blackshaw S
在生命早期的关键发育阶段，营养过剩或缺乏的环境会扰乱中枢进食和代谢神经回路的发育，导致成年期肥胖和代谢紊乱。更好地理解控制进食和代谢神经回路发育的基因网络，以及了解饮食信号如何及在何处扰乱这一过程，可为未来旨在扭转因全球肥胖流行而正在形成的公共卫生危机的治疗方法提供依据。对动物和人类研究的这篇综述强调了对调节中枢进食回路发育的分子机制、孕期和出生后早期营养状况影响这一过程的机制，以及旨在抵消早期过度喂养和喂养不足有害影响的方法的最新见解。
During critical periods of development early in life, excessive or scarce nutritional environments can disrupt the development of central feeding and metabolic neural circuitry, leading to obesity and metabolic disorders in adulthood. A better understanding of the genetic networks that control the development of feeding and metabolic neural circuits, along with knowledge of how and where dietary signals disrupt this process, can serve as the basis for future therapies aimed at reversing the public health crisis that is now building as a result of the global obesity epidemic. This review of animal and human studies highlights recent insights into the molecular mechanisms that regulate the development of central feeding circuitries, the mechanisms by which gestational and early postnatal nutritional status affects this process, and approaches aimed at counteracting the deleterious effects of early over- and underfeeding.