The transformative power of transformers in protein structure prediction.

The transformative power of transformers in protein structure prediction.
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蛋白质结构预测中的转换器的变革力量。

DOI:
10.1073/pnas.2303499120
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发表时间:
2023-08-08
影响因子:
11.1
通讯作者:
Bhattacharya, Debswapna
Bhattacharya, Debswapna
中科院分区:
综合性期刊1区
文献类型:
--
作者:
Moussad, Bernard;Roche, Rahmatullah;Bhattacharya, Debswapna

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变压器神经网络以前所未有的高精度预测蛋白质结构,彻底改变了结构生物学。在这里,我们报告了最近结束的第15届结构预测关键评估(CASP15)挑战中的69个蛋白质靶点的最先进的蛋白质结构预测方法的预测建模性能。我们的研究显示了变压器在蛋白质结构建模中的力量,并强调了未来的改进领域。
Transformer neural networks have revolutionized structural biology with the ability to predict protein structures at unprecedented high accuracy. Here, we report the predictive modeling performance of the state-of-the-art protein structure prediction methods built on transformers for 69 protein targets from the recently concluded 15th Critical Assessment of Structure Prediction (CASP15) challenge. Our study shows the power of transformers in protein structure modeling and highlights future areas of improvement.
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