Digital pulse contour analysis: investigating age-dependent indices of arterial compliance
Digital pulse contour analysis: investigating age-dependent indices of arterial compliance
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DOI：
10.1088/0967-3334/26/5/003
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发表时间：
2005-10-01
影响因子：
3.2
通讯作者：
Andrew, ME
中科院分区：
文献类型：
--
作者：
Brumfield, AM;Andrew, ME
采用一种自动确定平均脉搏函数的新算法，对3个年龄组（30-39岁、40-49岁、>= 50岁）的44名受试者的静息外周体积脉搏波进行了表征。静息平均脉搏的轮廓已根据其收缩期和舒张期特征进行了分析。先前描述的动脉硬度和粘弹性指数已经研究了与动脉力学性能相关的年龄依赖性变化。最小上升时间（MRT）和刚度指数（SI）的测量显示与年龄和彼此有很强的相关性，尽管它们的推导是无关的。虽然存在显著相关性（竖线r竖线= 0.50-0.78,p < 0.002），但右手和左手的最小上升时间参数两两比较没有显着差异；然而，左手的僵硬指数明显低于右手（p = 0.009）。在年龄方面，最年轻的年龄组的MRT和SI值明显低于两个年龄较大的组。对于这些数据，这仅在右手计算的参数中得到证明，因为左手在年龄组之间的差异较大。确定每个年龄组的标准化平均脉搏，直观地说明与MRT和SI参数相关的轮廓变化，这些变化发生在脉搏的收缩期和舒张期。研究发现，年龄组之间的差异在右手方面更为明显，这表明进行此类测试的物理位置可能是一个重要的考虑因素。这项研究提供了进一步的证据，证明在评估外周体积脉冲时使用轮廓分析的优点，以及为这种分析建立老化指数的重要性。
The resting peripheral volume pulse wave of 44 subjects within three age categories (30-39, 40-49, >= 50) has been characterized using a novel algorithm for the automated determination of a mean pulse function. The contour of this resting mean pulse has been analyzed with regard to its systolic and diastolic characteristics. Previously described indices of arterial stiffness and viscoelasticity have been investigated for age-dependent variations associated with arterial mechanical properties. Measures of the minimum rise time (MRT) and the stiffness index (SI) demonstrated strong correlations with age and each other, although their derivations are unrelated. While significant correlations existed (vertical bar r vertical bar = 0.50-0.78, p < 0.002), pairwise comparisons between the right and left hands did not demonstrate significant differences for the minimum rise time parameter; however, the stiffness index was significantly lower in the left hand versus the right (p = 0.009). With regard to age, the youngest age group had significantly lower MRT and SI values than the two older groups. For these data, this was only demonstrated in parameters calculated for the right hand because of higher variability within age groups for the left hand. A normalized average mean pulse for each age group was determined which visually illustrated the contour changes associated with the MRT and SI parameters that occur in both the systolic and diastolic portions of the pulse. The finding that differences between the age groups were significantly more evident for the right hand suggests that the physical site for such testing may be an important consideration. This study provides further evidence regarding the merit of using contour analysis when assessing the peripheral volume pulse and the importance of establishing ageing indices for such analysis.