Whole-heart modeling: applications to cardiac electrophysiology and electromechanics.
Whole-heart modeling: applications to cardiac electrophysiology and electromechanics.
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DOI：
10.1161/circresaha.110.223610
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发表时间：
2011-01-07
影响因子：
20.1
通讯作者：
Trayanova NA
中科院分区：
文献类型：
--
作者：
Trayanova NA
心脏模拟的最新发展使心脏成为虚拟器官中集成程度最高的例子。我们正处于心脏研究革命的边缘--在这场革命中，对蛋白质、细胞、组织和器官的计算建模允许将基因组和蛋白质组信息与综合器官行为联系起来，寻求提供对心脏在健康和疾病中的功能的定量了解。本文的目的是评估目前最先进的全心模型及其在心脏研究中的大量应用。介绍了全心模型的一般方法，综述了全心模型在心脏电生理学和电力学研究中的应用。本文展示了全心脏建模和仿真对我们理解心脏功能的贡献。对心脏模拟和建模领域的未来发展进行了总结。基于生物物理学的心脏计算模型应用于人类心脏生理学和心脏病的诊断和治疗，有可能极大地改变21世纪的心脏研究和心脏病学领域。
Recent developments in cardiac simulation have rendered the heart the most highly integrated example of a virtual organ. We are on the brink of a revolution in cardiac research–one in which computational modeling of proteins, cells, tissues and the organ allow to link genomic and proteomic information to the integrated organ behavior, in the quest to provide quantitative understanding of the functioning of the heart in health and disease. The goal of this article is to assess the current state-of-the-art in whole-heart modeling and the plethora of its applications in cardiac research. General whole-heart modeling approaches are presented, and the applications of whole-heart models in cardiac electrophysiology and electromechanics research are reviewed. The article showcases the contributions that whole-heart modeling and simulation have made to our understanding of the functioning of the heart. A summary of the future developments envisioned for the field of cardiac simulation and modeling is also presented. Biophysically-based computational modeling of the heart, applied to human heart physiology and the diagnosis and treatment of cardiac disease, has the potential to dramatically change twenty-first century cardiac research and the field of cardiology.