Gender-Specific Independent and Combined Effects of the Progesterone and 17-Hydroxyprogesterone on Metabolic Syndrome: From the Henan Rural Cohort Study.
Gender-Specific Independent and Combined Effects of the Progesterone and 17-Hydroxyprogesterone on Metabolic Syndrome: From the Henan Rural Cohort Study.
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黄体酮和 17-羟基黄体酮对代谢综合征的性别特异性独立和联合作用：来自河南农村队列研究
DOI：
10.2147/dmso.s332028
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发表时间：
2021
期刊：
影响因子：
--
通讯作者：
Huo W
中科院分区：
文献类型：
--
作者：
Wang M;Nie L;Wei D;Liu P;Zhang L;Fan K;Song Y;Wang L;Xu Q;Wang J;Liu X;Li L;Mao Z;Wang C;Huo W
背景虽然孕酮(P4)和17-羟孕酮(17-OHP)的浓度与代谢综合征(METS)的某些特征有关，但与METS的关系尚不确定。因此，我们用Mets研究了P4和17-OHP之间的关系。方法本研究共纳入4807名受试者。采用高效液相色谱-串联质谱法测定血清P4和17-OHP。用Logistic回归和限制三次样条法评价P4和17-OHP对蛋氨酸代谢的独立效应和联合效应。结果调整多因素后，绝经后妇女P4与METS呈正相关(第三胎与第一胎：OR=1.49，95%CI：1.20~1.86)，男性17-OHP与METS呈负相关(第三胎与第一胎：OR=0.43，95%CI：0.32~0.58)。与低P4和低17-OHP组合相比，高P4和高17-OHP组合与绝经后妇女METS显著相关(OR=1.71，95%CI：1.18~2.48)。男性低P4和高17-OHP与METS呈负相关(OR=0.41，95%CI：0.24~0.69)。结论绝经后妇女P4与METS呈正相关，而男性17-OHP与METS呈负相关。此外，它们的结合对绝经后妇女的甲硫氨酸转移酶有协同作用，对男性的甲硫氨酸转移酶有拮抗作用。
Background Although the concentrations of progesterone (P4) and 17-hydroxyprogesterone (17-OHP) have been correlated with some characteristics of metabolic syndrome (MetS), the relationships with MetS are inconclusive. Therefore, we investigated the relationship between P4 and 17-OHP with MetS. Methods In all, the present study includes 4807 participants. Serum P4 and 17-OHP were measured through liquid chromatography-tandem mass spectrometry. Logistic regression and restricted cubic splines were used to assess the independent and combined effects of P4 and 17-OHP on MetS. Results After adjusting for multiple variables, the positive association of P4 with MetS was observed in postmenopausal women (Third tertiles vs First tertiles: OR = 1.49, 95% CI: 1.20–1.86) and the negative association of 17-OHP with MetS was observed in men (Third tertiles vs First tertiles: OR = 0.43, 95% CI: 0.32–0.58). Compared with the combination of low P4 and low 17-OHP, the combination of high P4 and high 17-OHP were significantly related to MetS in postmenopausal women (OR = 1.71, 95% CI: 1.18–2.48). Moreover, the combination of low P4 and high 17-OHP was negatively associated with MetS in men (OR = 0.41, 95% CI: 0.24–0.69). Conclusion The association between P4 and MetS in postmenopausal women was positive, whereas 17-OHP was negatively associated with MetS in men. Additionally, their combination has a synergistic effect on MetS in postmenopausal women and an antagonistic effect on MetS in men.