POLYVALENT PNEUMOCOCCAL-POLYSACCHARIDE IMMUNIZATION OF PATIENTS WITH SICKLE-CELL-ANEMIA AND PATIENTS WITH SPLENECTOMY
POLYVALENT PNEUMOCOCCAL-POLYSACCHARIDE IMMUNIZATION OF PATIENTS WITH SICKLE-CELL-ANEMIA AND PATIENTS WITH SPLENECTOMY
复制标题
DOI：
10.1056/nejm197710272971701
复制
发表时间：
1977-01-01
影响因子：
158.5
通讯作者：
MENTZER, WC
中科院分区：
文献类型：
--
作者：
AMMANN, AJ;ADDIEGO, J;MENTZER, WC
为了降低脾功能减退患者肺炎链球菌感染的风险，对77例镰状细胞病患者和19例无脾患者接种了八价肺炎球菌疫苗，并将其反应与82例对照组（38例年龄匹配的正常人和44例正常的非洲黑人儿童）进行了比较。分别皮下注射50微克1、3、6、7、14、18、19和23型肺炎球菌多糖。免疫后血清（3-4周）可从52的77例镰状细胞病患者，反应的百分比和间接血凝反应的幅度是可比的控制。免疫后2年内8只S. 106例年龄匹配的未免疫镰状细胞病患者中检出肺炎支原体感染，而77例免疫组中未检出肺炎支原体感染（P < 0.025）。肺炎球菌多糖对脾功能减退患者具有免疫原性，可以预防全身性链球菌感染。肺炎感染。
To reduce the risk of infection from Streptococcus pneumoniae in hyposplenic patients octavalent pneumococcal vaccine was administered to 77 patients with sickle-cell disease and 19 asplenic persons and compared their response with 82 controls (38 age-matched normal persons and 44 normal black African children). Fifty micrograms each of pneumococcal-polysaccharide Types 1, 3, 6, 7, 14, 18, 19 and 23 were administered s.c. Post-immunization serums (3-4 wk) were available from 52 of 77 patients with sickle-cell disease; the percent responding and the magnitude of the indirect hemagglutination response were comparable to those of the controls. Within 2 yr after immunization 8 S. pneumoniae infections were observed in 106 age-matched unimmunized patients with sickle-cell disease, but none in the 77 immunized (P < 0.025). Pneumococcal polysaccharides are immunogenic in hyposplenic patients and may protect against systemic S. pneumoniae infection.