Immunological definition of leukemic cell surface phenotypes.
Immunological definition of leukemic cell surface phenotypes.
复制标题
白血病细胞表面表型的免疫学定义。
作者：
S. Melvin
对200多名急性淋巴细胞白血病(ALL)儿童的免疫表型分析显示，患者间的差异和个体患者原始细胞群体的表型异质性。由五个独立的淋巴细胞分化标记物组成的电池，即形成红细胞的花环。T细胞抗原、类Ia抗原、常见的ALL抗原和表面免疫球蛋白允许将所有标本分类为四个主要标记组。这些是常见的、T细胞、B细胞和未分化的ALL。在每个主要群体中观察到标记表型的异质性。在单个红细胞受体阳性的ALL标本中，原始细胞群体的表型异质性被证明。在疾病活动期对原始细胞表型的连续测定揭示了患者内原始细胞异质性的第二个例子。在对个别患者的序贯研究中，观察到治疗前和复发时的主要原始细胞种群的表型差异。这些表型的变化是非随机的。它们最常见的原因是单个分化标记的缺失。解释这些表型异质性的一个统一的假设是，所有的原始细胞都表现出有限的淋巴样分化。
Immunological phenotyping of blasts from over 200 children with acute lymphocytic leukemia (ALL) reveals both interpatient differences and phenotypic heterogeneity in the blast population from individual patients. A battery of five independent lymphocyte differentiation markers, erythrocyte-forming rosettes. T-cell antigens, Ia-like antigens, the common ALL antigen, and surface immunoglobulin, permit classification of all ALL specimens into four major marker groups. These are common, T-cell, B-cell, and undifferentiated ALL. Heterogeneity in the marker phenotypes within each of the major groups is observed. Within individual erythrocyte receptor-positive ALL specimens, phenotypic heterogeneity in the blast population is demonstrated. Sequential determinations of the blast phenotype during periods of active disease reveal a second example of intrapatient blast cell heterogeneity. Differences in phenotype of the dominant blast populations present prior to treatment and at relapse are observed in sequential studies of individual patients. These shifts in phenotype are nonrandom. They result most frequently from losses in single differentiation markers. A unifying hypothesis which explains these observations of phenotypic heterogeneity is that ALL blasts manifest limited lymphoid-like differentiation.