Diffusion-Weighted Images Differentiate Benign From Malignant Thyroid Nodules
Diffusion-Weighted Images Differentiate Benign From Malignant Thyroid Nodules
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DOI：
10.1002/jmri.22000
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发表时间：
2010-01-01
影响因子：
4.4
通讯作者：
Alkan, Alpay
中科院分区：
文献类型：
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作者：
Erdem, Gulnur;Erdem, Tamer;Alkan, Alpay
目的：通过与细针吸取细胞学(FNAC)结果的比较，揭示弥散加权成像(DWI)在甲状腺结节良恶性鉴别诊断中的可能作用。材料与方法：2005年12月至2007年5月，收治甲状腺良性结节27例，共52个良性结节，其中甲状腺恶性肿瘤9例，健康对照组24例。临床医生送至放射科进行活体组织检查的病例被纳入研究，以评估该地区的细胞病理学确认，超声检查，结果：甲状腺结节的平均表观扩散系数在良性组为2745.3+/-601.1×10(-6)mm(2)/S(1605-3899×10(-6)mm(2)/S)，恶性组为695.2+/-312.5×10(-6)mm(2)/S(165-1330x10(-6)mm(2)/S)。正常甲状腺组织平均ADC值为1344.1+/-276.4×10(-6)mm(2)/S(1015-1764x10(-6)mm(2)/S)。3个亚组ADC值差异有统计学意义(P=0.0001)。大多数患者的ADC值降低。结论：我们的初步结果显示，结节的ADC值可以为甲状腺结节的性质提供有用的数据。
Purpose: To reveal the possible role of diffusion-weighted images (DWI) in the differential diagnosis of benign and malignant thyroid nodules by comparing the results of fine-needle aspiration cytology (FNAC).Materials and Methods: In an 18-month period (December 2005 to May 2007), 27 cases with benign thyroid nodules with a total of 52 benign nodules, nine cases with thyroid gland malignancy and 24 healthy control cases were included in the study. Cases that were indicated to undergo to FNAC examination and sent by a clinician for biopsy to the radiology unit were included in the study to assess the cytopathologic confirmation of the clime, ultrasonographic, and magnetic resonance imaging (MRI) findings.Results: The mean apparent diffusion coefficient (ADC) values of thyroid nodules were 2745.3 +/- 601.1 x 10(-6) mm(2)/s (1605-3899 x 10(-6)mm(2)/s) in the benign group and 695.2 +/- 312.5 x 10(-6)mm(2)/s (165-1330 x 10(-6)mm(2)/s) in the malignant group. Normal thyroid tissues had mean ADC values of 1344.1 +/- 276.4 x 10(-6) mm(2)/s (1015-1764 x 10(-6)mm(2)/s). The ADC values of three subgroups were significantly different (P = 0.0001). A reduced ADC was observed in most. types of malignant tumors due to the consequent decrease of the extracellular extravascular space.Conclusion: Our preliminary results showed that ADC values of nodules may provide useful data about the nature of a thyroid nodule.