HIV drug development: the next 25 years
HIV drug development: the next 25 years
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DOI：
10.1038/nrd2336
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发表时间：
2007-12-01
影响因子：
120.1
通讯作者：
Flexner, Charles
中科院分区：
文献类型：
--
作者：
Flexner, Charles
25年前，HIV病毒被发现后不久，治疗HIV感染的药物就开始研发了。从那时起，取得了重大进展，但关于控制这种疾病的最佳方法仍然存在许多不确定性。在这里，我们回顾了目前的治疗方案，考虑了可以用于现有药物靶点的新机制，并探索了新靶点的潜力。展望未来25年，我们将考虑是否可以避免耐药性，哪些药物类别将比其他药物更受青睐，哪些策略最有可能成功，以及药物基因组学和个体化治疗的潜在影响。
The development of drugs for HIV infection began soon after the virus was discovered 25 years ago. Since then, progress has been substantial, but numerous uncertainties persist about the best way to manage this disease. Here we review the current treatment options, consider novel mechanisms that can be exploited for existing drug targets, and explore the potential of novel targets. With a view to the next quarter century, we consider whether drug resistance can be avoided, which drug classes will be favoured over others, which strategies are most likely to succeed, and the potential impact of pharmacogenomics and individualized therapy.