Vibrissa myoclonus (rhythmic retractions) driven by resonance of excitatory networks in motor cortex
Vibrissa myoclonus (rhythmic retractions) driven by resonance of excitatory networks in motor cortex
复制标题
DOI：
10.1152/jn.00454.2006
复制
发表时间：
2006-10-01
影响因子：
2.5
通讯作者：
Castro-Alamancos, Manuel A.
中科院分区：
文献类型：
--
作者：
Castro-Alamancos, Manuel A.
啮齿动物用有节奏的触须运动来感知环境。目前尚不清楚触须运动皮层（vMI）的内在活动是否能够逐周期驱动触须运动。vMI的去抑制导致自发的5- 15-Hz同步振荡的发生。在行为大鼠中，vMI的这种同步共振在这里被示出为驱动对侧触须运动，该运动被锁相到振荡的每个周期。与由主动延长组成的感测期间的主动搅动相反，由vMI振荡产生的触须运动由有节奏的缩回组成。结果表明，有节奏的运动皮层输出是能够驱动触须运动的一个周期的基础上。这种运动输出可能主要在异常状态期间表达，例如与皮质肌阵挛、震颤和皮质癫痫发作相关的那些状态。
Rodents use rhythmic vibrissae movements to sense the environment. It is currently unclear whether intrinsic activity in the vibrissa motor cortex (vMI) is capable of driving vibrissa movements on a cycle-by-cycle basis. Disinhibition of vMI results in the occurrence of spontaneous 5- to 15-Hz synchronized oscillations. In behaving rats, this synchronous resonance of vMI is shown here to drive contralateral vibrissa movements that are phase-locked to each cycle of the oscillation. In contrast to active whisking during sensing, which consists of active protractions, the vibrissa movements produced by vMI oscillations consisted of rhythmic retractions. The results demonstrate that rhythmic motor cortex output is capable of driving vibrissa movements on a cycle-by-cycle basis. Such motor output may be primarily expressed during abnormal states such as those related to cortical myoclonous, tremors, and cortical seizures.