Changes in Choroidal Thickness After Trabeculectomy in Primary Angle Closure Glaucoma
Changes in Choroidal Thickness After Trabeculectomy in Primary Angle Closure Glaucoma
复制标题
原发性闭角型青光眼小梁切除术后脉络膜厚度的变化。
DOI：
10.1167/iovs.13-13595
复制
发表时间：
2014-04-01
影响因子：
4.4
通讯作者：
Zhang, Xiulan
中科院分区：
文献类型：
--
作者：
Chen, Shida;Wang, Wei;Zhang, Xiulan
目的.本研究的目的是评估接受小梁切除术的晚期或晚期原发性闭角型青光眼（PACG）患者脉络膜厚度（CT）的变化。该研究包括23只需要小梁切除术的PACG眼睛。采用增强型深度成像光学相干断层扫描仪测量小梁切除术前和术后7天的CT值。探讨CT改变与眼压及眼轴变化的关系。在所有9个黄斑部位，小梁切除术后CT值显著升高，但有两个部位除外。手术后，靠近黄斑位置的CT显示出更大的增加（下方位置除外），尽管与远离黄斑的位置相比没有显著差异。术前和术后中心凹下的平均CT（+/- SD）分别为282.3（+/- 42.4）μ m和311.6（+/- 59.9）μ m。平均IOP（+/- SD）从25.9（+/- 11.0）mm Hg降至11.8（+/- 3.2）mm Hg（未使用抗青光眼药物），这与术后眼轴长度缩短呈正相关（P = 0.019）。然而，CT的变化与眼压或眼轴长度无关。PACG患者小梁切除术后短期CT增加，但与眼压降低或眼轴缩短无关。小梁切除术后CT升高的潜在作用和意义仍有待解释。
PURPOSE. The purpose of this study was to evaluate changes in choroidal thickness (CT) in advanced or late-stage primary angle closure glaucoma (PACG) patients who had undergone trabeculectomy.METHODS. This study included 23 eyes with PACG that required trabeculectomy. Enhanced depth imaging optical coherence tomography was used to measure CT before and 7 days after trabeculectomy. The relationships between changes in CT and changes in IOP and axial length were explored.RESULTS. At all nine macular locations, CT was significantly higher after trabeculectomy, with the exception of two sites. CT at locations close to the macula exhibited a greater increase after surgery (except for the inferior location), although there were no significant differences compared to locations farther from the macula. The mean CTs (+/- SD) under the fovea before and after the surgery were 282.3 (+/- 42.4) mu m and 311.6 (+/- 59.9) mu m, respectively. The mean IOP (+/- SD) decreased from 25.9 (+/- 11.0) mm Hg to 11.8 (+/- 3.2) mm Hg (without antiglaucoma medications), which positively related to the shortened axial length after surgery (P = 0.019). However, the changes in CT were not correlated with either IOP or axial length.CONCLUSIONS. Short-term CT increased following trabeculectomy in PACG, but it was not related to decreased IOP or shortened axial length. The potential role for and significance of CT increase after trabeculectomy remains to be interpreted.