Cancer incidence in a cohort of licensed pesticide applicators in Florida
Cancer incidence in a cohort of licensed pesticide applicators in Florida
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DOI：
10.1097/00043764-199904000-00010
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发表时间：
1999-04-01
影响因子：
3.2
通讯作者：
Hamilton, K
中科院分区：
文献类型：
--
作者：
Fleming, LE;Bean, JA;Hamilton, K
这项研究是一个标准化的发病率比（SIR）分析癌症发病率的持牌农药施用者在佛罗里达，与佛罗里达的一般人口相比。通过广泛的数据链接，收集了33，658名施用者，他们从1975年1月1日至1993年12月31日发生了1266起癌症事件和279，397人年。在男性中，前列腺癌（SIR = 1.91; 95%置信区间[CI]，1.72-2.13）和睾丸癌（SIR = 2.48; 95% CI，1.57-3.72）显著升高。未发现软组织肉瘤（STS）确诊病例，非霍奇金淋巴瘤发病率未增加。女性施用者很少;然而，宫颈癌的发病率（SIR = 3.69; 95% CI，1.84-6.61）显著增加，而乳腺癌的发病率显著降低。与雌激素干扰物有关的癌症在男性农药施用者中发现，但在女性农药施用者中没有发现。缺乏软组织肉瘤是在与苯氧基除草剂的使用相关的先前文献不一致。
This study is a standardized incidence ratio (SIR) analysis of cancer incidence of licensed pesticide applicators in Florida, compared with that of Florida's general population. Through extensive data linkages, 33,658 applicators were assembled who had 1266 incident cancers and 279,397 person-years from January 1, 1975, to December 31, 1993. Among males, prostate cancer (SIR = 1.91; 95% confidence interval [CI], 1.72-2.13) and testicular cancer (SIR = 2.48; 95% CI, 1.57-3.72) were significantly elevated. No confirmed cases of soft tissue sarcoma (STS) were found, and the incidence of non-Hodgkin's lymphoma was not increased. There were few female applicators; nevertheless, cervical cancer incidence (SIR = 3.69; 95% CI, 1.84-6.61) was significantly increased, while the incidence of breast cancer was significantly decreased. Cancers that have been associated with estrogen disrupters were found in male, but not female, pesticide applicators. The lack of soft tissue sarcoma is at odds with prior literature associated with the use of phenoxy herbicides.