Prognosis of ischemia recurrence in patients with moderate intracranial atherosclerotic disease using quantitative MRA measurements.
Prognosis of ischemia recurrence in patients with moderate intracranial atherosclerotic disease using quantitative MRA measurements.
复制标题
使用定量 MRA 测量对中度颅内动脉粥样硬化性疾病患者的缺血复发进行预后。
DOI：
10.1117/12.2611462
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发表时间：
2022
期刊：
影响因子：
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通讯作者：
Ionita,CiprianN
中科院分区：
文献类型：
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作者：
Joseph,Jeff;Weppner,Benjamin;Pinter,NandorK;ShirazBhurwani,MohammadMahdi;Monteiro,Andre;Baig,Ammad;Davies,Jason;Siddiqui,Adnan;Ionita,CiprianN
目的探讨无创性最佳血管分析(NOVA)MRI检测迟发性缺血性卒中与颅内动脉粥样硬化性疾病(ICAD)血流动力学的关系。所有患者都接受了临床指征的血管成形术，然后在3.0Tesla磁共振扫描仪上使用16通道神经血管线圈或32通道头部线圈进行二维相位对比磁共振(2D PCMR)。使用非侵入性最佳血管分析(NOVA)软件(VasSol，芝加哥，伊利诺伊州，美国)从2D PCMR计算体积流速测量。在Willis环的远端、近端和内部的20条主要动脉上进行了流速测量。术后随访6个月，记录缺血复发情况及部位。受试者工作特性(ROC)分析使用血流速度测量在缺血事件发生的同侧进行。结果34例患者完成全套测量。左、右半球缺血复发分别为7例和3例。预测脑缺血事件复发的最佳指标是大脑中动脉血流速度，其ROC下面积为0.821±0.109。结论本研究旨在探讨颅内血管血流测量是否能预测未来的脑缺血事件。我们的结果表明，使用NOVA软件处理的2D PCMR的血流测量结果与缺血复发之间存在显著的相关性。这些结果支持进一步研究使用该方法对ICAD患者进行风险分层。
PurposeTo investigate the relation between delayed ischemic stroke and the intracranial atherosclerotic disease (ICAD) hemodynamics as determined by Non-invasive Optimal Vessel Analysis (NOVA) MRI measurements.Materials and MethodsThirty-three patients with ICAD were enrolled in this study. All patients underwent clinically indicated angioplasty followed by 2-dimensional phase contrast MR (2D PCMR) performed on a 3.0 Tesla MRI scanner using either a 16-channel neurovascular coil or 32-channel head coil. The volumetric flow rate measurements were calculated from 2D PCMR with Non-invasive Optimal Vessel Analysis (NOVA) software (VasSol, Chicago, IL, USA). Flow rate measurements were obtained in 20 major arteries distal, proximal and within the Circle of Willis. Patients were followed up for six month, and ischemia reoccurrence and location were recorded. Receiver operating characteristic (ROC) analysis was performed using flow rates measurements in the ipsilateral side of the ischemic event occurrence. Results Complete set of measurements was achieved in n=34. Left and right hemisphere ischemia recurrence was observed in seven and three cases respectively. Best predictor of ischemic event reoccurrence was flow rate in the middle cerebral artery with area under the ROC of 0.821±0.109.ConclusionsThis is an effectiveness study to determine whether blood flow measurements in the intracranial vasculature may be predictive of future ischemic events. Our results demonstrated significant correlation between the blood flow measurements using 2D PCMR processed with the NOVA software and the reoccurrence of ischemia. These results support further investigation for using this method for risk stratification of ICAD patients.