Who comes first? The role of the prefrontal and parietal cortex in cognitive control
Who comes first? The role of the prefrontal and parietal cortex in cognitive control
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DOI：
10.1162/0898929054985400
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发表时间：
2005-09-01
影响因子：
3.2
通讯作者：
Phillips, NA
中科院分区：
文献类型：
--
作者：
Brass, M;Ullsperger, M;Phillips, NA
认知控制过程使我们能够调整我们的行为以适应不断变化的环境需求。虽然神经心理学研究表明，认知控制的关键皮层区域是前额叶皮层，但神经成像研究强调了前额叶皮层和顶叶皮层的相互作用。这就提出了一个基本问题，即前额叶和顶叶区域在认知控制中的不同作用。据推测，前额叶皮层偏向后脑区域的处理。这个假设导致了这样一个假设，即在认知控制中，前额叶皮层的神经活动应该先于顶叶的活动。本研究通过结合功能磁共振成像（fMRI）提供高空间分辨率和事件相关电位（ERP）获得高时间分辨率的结果来验证这一假设。我们使用修改后的任务切换范式收集了ERP数据。在这个范例中，一个情况下，相同的任务是由两个不同的线索指示的情况下，两个线索指示不同的任务进行了比较，只有后者的条件需要更新的任务集。任务集更新与中线负ERP偏转峰值约470毫秒。我们将偶极子在以前的功能磁共振成像研究中使用相同的范式（左额下交界处，右额下回，右顶叶皮层）激活的区域，并拟合其方向和幅度的ERP效果。额叶偶极子的ERP效应早于顶叶偶极子，提供支持的观点，即前额叶皮层参与更新的一般任务表征和偏见相关的刺激反应协会顶叶皮层。
Cognitive control processes enable us to adjust our behavior to changing environmental demands. Although neuropsychological studies suggest that the critical cortical region for cognitive control is the prefrontal cortex, neuro-imaging studies have emphasized the interplay of prefrontal and parietal cortices. This raises the fundamental question about the different contributions of prefrontal and parietal areas in cognitive control. It was assumed that the prefrontal cortex biases processing in posterior brain regions. This assumption leads to the hypothesis that neural activity in the prefrontal cortex should precede parietal activity in cognitive control. The present Study tested this assumption by combining results from functional magnetic resonance imaging (fMRI) providing high spatial resolution and event-related potentials (ERPs) to gain high temporal resolution. We collected ERP data using a modified task-switching paradigm. In this paradigm, a situation where the same task was indicated by two different cues was compared with a situation where two cues indicated different tasks, Only the latter condition required updating of the task set. Task-set updating was associated with a midline negative ERP deflection peaking around 470 msec. We placed dipoles in regions activated in a previous fMRI study that used the same paradigm (left inferior frontal junction, right inferior frontal gyrus, right parietal Cortex) and fitted their directions and magnitudes to the ERP effect. The frontal dipoles contributed to the ERP effect earlier than the parietal dipole, providing support for the view that the prefrontal cortex is involved in updating of general task representations and biases relevant stimulus-response associations in the parietal cortex.