GLIAL HYPERTROPHY IS ASSOCIATED WITH SYNAPTOGENESIS FOLLOWING MOTOR-SKILL LEARNING, BUT NOT WITH ANGIOGENESIS FOLLOWING EXERCISE
GLIAL HYPERTROPHY IS ASSOCIATED WITH SYNAPTOGENESIS FOLLOWING MOTOR-SKILL LEARNING, BUT NOT WITH ANGIOGENESIS FOLLOWING EXERCISE
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DOI：
10.1002/glia.440110110
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发表时间：
1994-05-01
期刊：
影响因子：
6.2
通讯作者：
GREENOUGH, WT
中科院分区：
文献类型：
--
作者：
ANDERSON, BJ;LI, XC;GREENOUGH, WT
在复杂环境中断奶的大鼠1）神经胶质表面积增加，2）毛细血管体积增加，3）每个神经元的突触数量增加。在该范例中，尚不可能确定胶质细胞的增加是否与突触数量的增加或与血管生成更密切相关。最近我们发现，运动的大鼠毛细血管密度增加，但突触数量没有增加，而学习新运动技能的大鼠每个神经元的突触数量更多，但毛细血管密度没有增加。这些发现为研究小脑胶质细胞体积的变化是否与突触数量或毛细血管体积的变化相对应提供了机会。神经胶质面积分数的估计，获得了电子显微照片上的点计数从以前的研究。技能学习组有一个更大的体积的分子层每浦肯野细胞，也有一个更大的体积的胶质细胞每浦肯野细胞，比大鼠在任何一个非活动组或大鼠在两个运动组。各组间每个突触的胶质细胞体积和每个毛细血管的胶质细胞体积无显著差异，尽管运动组每个毛细血管的胶质细胞体积有降低的趋势。这些数据表明，神经胶质细胞的体积与突触的数量，而不是与毛细血管密度。(C)1994 Wiley-Liss，Inc.
Rats reared from weaning in a complex environment have an increase in 1) glial surface area, 2) capillary volume, and 3) the number of synapses, per neuron. In that paradigm it has not been possible to determine whether the glial increase more closely correlates with the increase in synaptic numbers or with angiogenesis. More recently we have found that rats that exercised had an increase in the density of capillaries without an increase in the synaptic numbers, whereas rats that learned new motor skills had a greater number of synapses per neuron without an increase in the density of capillaries. Those findings provided the opportunity to investigate whether changes in glial volume in the cerebellum correspond to changes in the number of synapses or in capillary volume. Glial area fraction estimates were obtained using point counts on electron micrographs from the previous studies. The skill learning group had a greater volume of molecular layer per Purkinje cell, and also a greater volume of glia per Purkinje cell, than rats in either an inactive group or rats in two exercise groups. No significant differences were found in glial volume per synapse and glial volume per capillary across groups, although there was a tendency for glial volume per capillary to be lower in the exercise groups. The data indicate that glial volume correlates with synaptic numbers and not with capillary density. (C) 1994 Wiley-Liss, Inc.