Chemical Ototoxicity of the Fish Inner Ear and Lateral Line
Chemical Ototoxicity of the Fish Inner Ear and Lateral Line
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DOI：
10.1007/978-3-319-21059-9_18
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发表时间：
2016-01-01
期刊：
影响因子：
--
通讯作者：
Ramcharitar, John
中科院分区：
文献类型：
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作者：
Coffin, Allison B.;Ramcharitar, John
毛细胞驱动的机械感觉系统对于鱼类成功执行许多行为至关重要，并且已经成为探索与人类听觉相关问题的良好模型。本文就鱼类内耳和侧线系统的耳毒性作用作一综述。我们特别检查了化学耳毒素如氨基糖苷类抗生素作为禁用侧线的工具的研究。侧线烧蚀导致各种物种的摄食行为和水流方向的改变。然而，这两种行为都没有被废除的存在下，额外的感官线索，支持的假设，许多鱼类的行为是由多感官整合。在生物医学研究中，斑马鱼幼虫侧线已成为了解毛细胞死亡的信号机制和开发保护毛细胞免受耳毒性损伤的新型药理学疗法的重要模型系统。此外，鉴于鱼类能稳健地再生受损的毛细胞，鱼类的耳毒素研究拓宽了我们对先天再生系统中分子和遗传事件的理解，为哺乳动物毛细胞再生提供了潜在的靶点。总的来说，鱼类机械感觉系统的研究已经深入了解鱼类的行为和毛细胞死亡，保护和再生的机制。
Hair cell-driven mechanosensory systems are crucial for successful execution of a number of behaviors in fishes, and have emerged as good models for exploring questions relevant to human hearing. This review focuses on ototoxic effects in the inner ear and lateral line system of fishes. We specifically examine studies where chemical ototoxins such as aminoglycoside antibiotics have been employed as tools to disable the lateral line. Lateral line ablation results in alterations to feeding behavior and orientation to water current in a variety of species. However, neither behavior is abolished in the presence of additional sensory cues, supporting the hypothesis that many fish behaviors are driven by multisensory integration. Within biomedical research, the larval zebrafish lateral line has become an important model system for understanding signaling mechanisms that contribute to hair cell death and for developing novel pharmacological therapies that protect hair cells from ototoxic damage. Furthermore, given that fishes robustly regenerate damaged hair cells, ototoxin studies in fishes have broadened our understanding of the molecular and genetic events in an innately regenerative system, offering potential targets for mammalian hair cell regeneration. Collectively, studies of fish mechanosensory systems have yielded insight into fish behavior and in mechanisms of hair cell death, protection, and regeneration.