What is the function of mitochondrial networks? A theoretical assessment of hypotheses and proposal for future research.
What is the function of mitochondrial networks? A theoretical assessment of hypotheses and proposal for future research.
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DOI：
10.1002/bies.201400188
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发表时间：
2015-06
期刊：
影响因子：
--
通讯作者：
Jones NS
中科院分区：
文献类型：
--
作者：
Hoitzing H;Johnston IG;Jones NS
线粒体可以改变其形状，从离散的孤立细胞器到一个大的连续网状。这些融合网络背后的蜂窝优势仍未被完全理解。在本文中，我们描述和比较关于线粒体网络功能的假设。我们使用数学和物理工具来调查现有的假设并产生新的假设，我们建议实验和建模策略。我们从这项工作中强调的新见解包括：(i)选择性有丝分裂不需要质量控制，因为选择性融合就足够了；（ii）连通性的增加可能对蛋白质的扩散速率产生非线性影响；（三）融合网络可以抑制生化波动。我们希望向读者传达定量方法可以推动这些形态变化的生理优势的理解的进步。
Mitochondria can change their shape from discrete isolated organelles to a large continuous reticulum. The cellular advantages underlying these fused networks are still incompletely understood. In this paper, we describe and compare hypotheses regarding the function of mitochondrial networks. We use mathematical and physical tools both to investigate existing hypotheses and to generate new ones, and we suggest experimental and modelling strategies. Among the novel insights we underline from this work are the possibilities that (i) selective mitophagy is not required for quality control because selective fusion is sufficient; (ii) increased connectivity may have non-linear effects on the diffusion rate of proteins; and (iii) fused networks can act to dampen biochemical fluctuations. We hope to convey to the reader that quantitative approaches can drive advances in the understanding of the physiological advantage of these morphological changes.