Human dermal fibroblasts in psychiatry research.
Human dermal fibroblasts in psychiatry research.
复制标题
人类皮肤成纤维细胞在精神病学研究中。
DOI：
10.1016/j.neuroscience.2016.01.067
复制
发表时间：
2016-04-21
期刊：
影响因子：
3.3
通讯作者：
Mirnics K
中科院分区：
文献类型：
--
作者：
Kálmán S;Garbett KA;Janka Z;Mirnics K
为了破译疾病的病因，进展和治疗的多因素人类大脑疾病，我们利用了不同的实验模型主机。最近，患者来源的人皮肤成纤维细胞（HDF）培养物已重新成为有前途的体外功能系统，用于检查各种细胞，分子，代谢和（病理）生理状态和精神疾病的特征。HDF研究可作为尸检和动物研究的有力补充，通常可提供有关神经组织内稳态改变的信息。对患有精神分裂症、抑郁症、双相情感障碍、自闭症、注意力缺陷多动障碍和其他精神疾病的患者的HDF的研究显著地促进了我们对这些毁灭性疾病的理解。这些报告明确证明，信号转导、氧化还原稳态、昼夜节律和基因 * 环境相互作用都适合HDF模型评估。此外，报告的研究结果表明，这种未充分利用的患者生物材料，结合现代分子生物学技术，可能具有诊断和预后价值，包括预测对治疗药物的反应。
In order to decipher the disease etiology, progression and treatment of multifactorial human brain diseases we utilize a host of different experimental models. Recently, patient-derived human dermal fibroblast (HDF) cultures have re-emerged as promising in vitro functional system for examining various cellular, molecular, metabolic and (patho)physiological states and traits of psychiatric disorders. HDF studies serve as a powerful complement to postmortem and animal studies, and often appear to be informative about the altered homeostasis in neural tissue. Studies of HDFs from patients with schizophrenia, depression, bipolar disorder, autism, attention deficit and hyperactivity disorder and other psychiatric disorders have significantly advanced our understanding of these devastating diseases. These reports unequivocally prove that signal transduction, redox homeostasis, circadian rhythms and gene*environment interactions are all amenable for assessment by the HDF model. Furthermore, the reported findings suggest that this underutilized patient biomaterial, combined with modern molecular biology techniques, may have both diagnostic and prognostic value, including prediction of response to therapeutic agents.