Dearomative logic in natural product total synthesis.
Dearomative logic in natural product total synthesis.
复制标题
天然产物全合成中的脱香逻辑。
DOI：
10.1039/d2np00042c
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发表时间：
2022-12-14
影响因子：
11.9
通讯作者：
中科院分区：
文献类型：
--
作者：
The natural world is a prolific source of some of the most interesting, rare, and complex molecules known, harnessing sophisticated biosynthetic machinery evolved over billions of years for their production. Many of these natural products represent high-value targets of total synthesis, either for their desirable biological activities or for their beautiful structures outright; yet, the high sp3-character often present in nature’s molecules imparts significant topological complexity that pushes the limits of contemporary synthetic technology. Dearomatization is a foundational strategy for generating such intricacy from simple materials that has undergone considerable maturation in recent years. This review highlights the recent achievements in the field of dearomative methodology, with a focus on natural product total synthesis and retrosynthetic analysis. Disconnection guidelines and a three-phase dearomative logic are described, and a spotlight is given to nature’s use of dearomatization in the biosynthesis of various classes of natural products. Synthetic studies from 2011 to 2021 are reviewed, and 425 references are cited.
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影响因子：
15
作者：
Cernijenko A;Risgaard R;Baran PS
通讯作者：
Baran PS
影响因子：
5.2
作者：
Hayashi R;Ma ZX;Hsung RP
通讯作者：
Hsung RP
DOI：
10.1016/bs.alkal.2015.08.001
发表时间：
2016-01-01
期刊：
The Alkaloids. Chemistry and biology
影响因子：
--
作者：
Adams, Gregory L;Smith, Amos B 3rd
通讯作者：
Smith, Amos B 3rd
影响因子：
3.5
作者：
Baliga, MS;Jagetia, GC;Bairy, KL
通讯作者：
Bairy, KL
影响因子：
5.2
作者：
Baitinger, Irina;Mayer, Peter;Trauner, Dirk
通讯作者：
Trauner, Dirk