HnRNP proteins: Localization and transport between the nucleus and the cytoplasm
HnRNP proteins: Localization and transport between the nucleus and the cytoplasm
复制标题
DOI：
10.1016/0962-8924(93)90135-n
复制
发表时间：
1993-01-01
影响因子：
19
通讯作者：
Dreyfuss, Gideon
中科院分区：
文献类型：
--
作者：
Pinol-Roma, Serafin;Dreyfuss, Gideon
异质核核糖核蛋白（hnRNP）复合物蛋白是细胞核中最丰富的蛋白质之一。它们结合新生的前mRNA，并通过其核加工成mRNA与它们保持结合。最近的研究结果表明hnRNP蛋白在mRNA的生物合成中的作用，并揭示了这些蛋白质的一个令人惊讶的细胞内定位途径。几种hnRNP蛋白在细胞核和细胞质之间连续穿梭，并且输出的hnRNP蛋白在细胞核中的再积累通过依赖于RNA聚合酶II的转录的新过程发生。这些研究结果表明，hnRNP蛋白在细胞质和mRNA的核质运输可能的新功能。
The proteins of heterogeneous nuclear ribonucleoprotein (hnRNP) complexes are among the most abundant proteins in the nucleus. They bind nascent pre-mRNAs and remain associated with them through their nuclear processing into mRNA. Recent findings indicate roles for hnRNP proteins in the biogenesis of mRNA and reveal a surprising intracellular localization pathway for these proteins. Several of the hnRNP proteins shuttle continuously between the nucleus and the cytoplasm, and the reaccumulation of the exported hnRNP proteins in the nucleus occurs by a novel process that is dependent on transcription by RNA polymerase II. These findings suggest possible novel functions for hnRNP proteins in the cytoplasm and in the nucleocytoplasmic transport of mRNA.