Histopathological analysis of the association between mucosal epithelial changes and the lamina propria vascular network in irritation fibroma
Histopathological analysis of the association between mucosal epithelial changes and the lamina propria vascular network in irritation fibroma
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刺激性纤维瘤粘膜上皮变化与固有层血管网关系的组织病理学分析
DOI：
10.1016/j.job.2021.07.002
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发表时间：
2021
影响因子：
2.4
通讯作者：
Tsukinoki Keiichi
中科院分区：
文献类型：
--
作者：
Amano Rie;Saruta Juri;Sakaguchi Wakako;Kubota Nobuhisa;Fuchida Shinya;Tsukinoki Keiichi
目的：口腔内的刺激性纤维瘤可引起萎缩或鳞状上皮增厚，与外伤相关因素有关。然而，大多数情况下不会发生溃疡。本研究的目的是阐明溃疡不形成的机制，专注于刺激性纤维瘤的粘膜上皮中的血管网络。方法：采用酶抗体法进行免疫组织化学染色，用抗CD 31和Ki-67的一抗在17例颊粘膜刺激性纤维瘤。在距边缘3个点和距病变正上方3个点处取一个切片进行测量。结果：病变上皮正下方浅层固有层血管的数量和面积均小于边缘处血管的数量和面积，病变上皮正下方浅层固有层血管的数量和面积小于边缘处血管的数量和面积。边缘和病变深层固有层血管的数量和面积无差异。结论：我们的研究结果表明，深层固有层中的血管网络得以维持，并补偿了对覆盖上皮的营养供应。© 2021日本口腔生物学协会。出版社：Elsevier BV版权所有。
Objectives: Irritation fibroma in the oral cavity causes atrophy or squamous epithelium thickening with respect to external injury-associated factors. However, ulcers do not occur in most cases. This study aimed to elucidate the mechanism by which ulcers do not form, focusing on the vascular network in the mucosal epithelium of irritation fibroma.Methods: Immunostaining was performed using an enzyme antibody method with primary antibodies against CD31 and Ki-67 in 17 cases of irritation fibroma in the buccal mucosa. One section was taken at three points from the margin and three points from just above the lesion for measurement. The number of blood vessels in the superficial and deep lamina propria at the measurement site were determined, and the area per blood vessel was measured.Results: The number and area of blood vessels in the superficial lamina propria just below the lesion epithelium were smaller than those in the margin. No difference was observed in the number and area of blood vessels in the deep lamina propria between the margins and lesions. Conclusions: Our results suggest that the vascular network in the deep lamina propria is maintained and compensates for the nutrient supply to the covering epithelium.© 2021 Japanese Association for Oral Biology. Published by Elsevier BV All rights reserved.