Changes in ipsilesional hand motor function differ after unilateral injury to frontal versus frontoparietal cortices in Macaca mulatta
Changes in ipsilesional hand motor function differ after unilateral injury to frontal versus frontoparietal cortices in Macaca mulatta
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DOI：
10.1007/s00221-019-05690-0
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发表时间：
2020-01-01
影响因子：
2
通讯作者：
Morecraft, Robert J.
中科院分区：
文献类型：
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作者：
Darling, Warren G.;Pizzimenti, Marc A.;Morecraft, Robert J.
我们测试的假设，额顶叶感觉运动区的损伤会导致更大的初始损伤的性能和更差的恢复同病灶灵巧的手/手指运动比病变局限于额叶运动区的恒河猴。损伤后6-12个月，使用两项运动测试评估同侧手达到和抓握/操作小目标的能力。在两组猴子中比较损伤后的初始运动技能和运动技能的长期恢复：（1）F2组-五例初级运动皮层（M1）和外侧运动前皮层（LPMC）的臂区损伤和（2）F2 P2组-五例F2损伤+初级体感皮层的臂区和5区前部损伤。在困难精细运动任务中，大多数F2病变病例的初始病变后触及和操作技能与病变前技能相似或更好，但在所有任务中，大多数F2 P2病变病例的初始病变后触及和操作技能均比病变前技能差。随后，达到和操作技能改善后病变期间高于病变前的技能，在两组，但改善更大的F2病变组，可能是由于额外的任务实践和更多的同侧肢体使用的日常活动。在F2 P2病例中，损伤后同侧上肢运动技能的明显和缓慢的改善可能是由于躯体感觉处理受损。在人类中风后经常观察到的持续性同侧上肢运动缺陷可能是由皮质下白色和灰质损伤引起的，而不是在这里研究的局部手术损伤。
We tested the hypothesis that injury to frontoparietal sensorimotor areas causes greater initial impairments in performance and poorer recovery of ipsilesional dexterous hand/finger movements than lesions limited to frontal motor areas in rhesus monkeys. Reaching and grasping/manipulation of small targets with the ipsilesional hand were assessed for 6-12 months post-injury using two motor tests. Initial post-lesion motor skill and long-term recovery of motor skill were compared in two groups of monkeys: (1) F2 group-five cases with lesions of arm areas of primary motor cortex (M1) and lateral premotor cortex (LPMC) and (2) F2P2 group-five cases with F2 lesions + lesions of arm areas of primary somatosensory cortex and the anterior portion of area 5. Initial post-lesion reach and manipulation skills were similar to or better than pre-lesion skills in most F2 lesion cases in a difficult fine motor task but worse than pre-lesion skill in most F2P2 lesion cases in all tasks. Subsequently, reaching and manipulation skills improved over the post-lesion period to higher than pre-lesion skills in both groups, but improvements were greater in the F2 lesion group, perhaps due to additional task practice and greater ipsilesional limb use for daily activities. Poorer and slower post-lesion improvement of ipsilesional upper limb motor skill in the F2P2 cases may be due to impaired somatosensory processing. The persistent ipsilesional upper limb motor deficits frequently observed in humans after stroke are probably caused by greater subcortical white and gray matter damage than in the localized surgical injuries studied here.