Validation of the Leicester Cough Questionnaire in non-cystic fibrosis bronchiectasis
Validation of the Leicester Cough Questionnaire in non-cystic fibrosis bronchiectasis
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DOI：
10.1183/09031936.00160508
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发表时间：
2009-07-01
影响因子：
24.3
通讯作者：
Hill, A. T.
中科院分区：
文献类型：
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作者：
Murray, M. P.;Turnbull, K.;Hill, A. T.
健康相关的生活质量是评估支气管扩张症现有和新疗法的潜在重要指标。莱斯特咳嗽问卷（LCQ）是一种症状特异性问卷，旨在评估咳嗽严重程度（支气管扩张的主要症状）的影响。本研究旨在验证LCQ在支气管扩张症中的有效性、反应性和可靠性，评估LCQ的有效性、反应性和可靠性如下：区分严重和轻度疾病的能力;急性加重抗生素治疗后评分的变化;稳定疾病6个月内的重复性;共120例患者（51例重症，29例中度，40例轻度）完成了LCQ和SGRQ。重度和轻度疾病的受试者-操作者曲线下面积均良好（分别为0.84和0.80，p
Health-related quality of life is a potentially important marker for evaluating existing and new therapies in bronchiectasis. The Leicester Cough Questionnaire (LCQ) is a symptom specific questionnaire designed to assess the impact of cough severity, a major symptom of bronchiectasis. This study aimed to validate the LCQ in bronchiectasis.The validity, responsiveness and reliability of the LCQ were assessed as follows: ability to discriminate severe and mild disease; change in score following antibiotic treatment for exacerbations; repeatability over a 6-month period in stable disease; and comparison with the St George's Respiratory Questionnaire (SGRQ).In total, 120 patients (51 with severe disease, 29 with moderate disease and 40 with mild disease) completed the LCQ and SGRQ. The area under the receiver-operator curve was good for both severe and mild disease (0.84 and 0.80 respectively, p