Chromosome mapping of the mouse Akt2 gene and Akt2 pseudogene.
Chromosome mapping of the mouse Akt2 gene and Akt2 pseudogene.
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小鼠 Akt2 基因和 Akt2 假基因的染色体定位。
DOI：
10.1159/000134426
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发表时间：
1996
期刊：
影响因子：
--
通讯作者：
Testa,JR
中科院分区：
文献类型：
--
作者：
Altomare,DA;Kozak,CA;Sonoda,G;Testa,JR
我们以前报道的小鼠编码蛋白质丝氨酸/苏氨酸激酶Akt 2的cDNA的克隆，我们用这个克隆映射Akt 2基因小鼠染色体（MMU）7 B1的荧光原位杂交。我们现在已经克隆并部分测序了小鼠Akt 2假基因。两组多位点杂交的分析表明，Akt 2基因是紧密连锁的近端MMU 7中的Cyp 2a位点。通过多位点定位和荧光原位杂交将Akt 2假基因定位到MMU 11的近端。
We previously reported the cloning of a murine cDNA encoding the protein-serine/threonine kinase Akt2, and we used this clone to map the Akt2 gene to mouse chromosome (MMU) 7B1 by fluorescence in situ hybridization. We now have cloned and partially sequenced a mouse Akt2 pseudogene. An analysis of two sets of multilocus crosses revealed that the Akt2 gene is closely linked to the Cyp2a locus in proximal MMU7. The Akt2 pseudogene was mapped to proximal MMU11 by both multilocus mapping and fluorescence in situ hybridization.