Biomimetic and Bioinspired Biotechnology
Biomimetic and Bioinspired Biotechnology
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仿生和仿生生物技术
DOI：
10.1002/biot.201800670
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发表时间：
2018
影响因子：
4.7
通讯作者：
Gotoh Takeshi
中科院分区：
文献类型：
--
作者：
Bentley William E.;Martin Donald K.;Gotoh Takeshi
我们努力构建与生物学紧密结合和相互作用的设备，这导致了“生物制造”和“4D打印”等概念，表现出模仿自然的愿望，并确实将天然产品纳入提供增强功能的结构中，特别是在与生物学相互作用，发出信号甚至与生物学交流的能力方面。在《生物技术杂志》的这期特刊中，我们邀请了几位著名学者提供文章，描述了利用生物材料进行组装的努力，以及利用或模仿生物组装过程来构建具有高级功能的组件和系统。本期是2017年秋季在日本秋田举行的“第8届资源材料工程国际会议”的成果，该会议由大冢和夫博士、永井义雄博士、吉村升博士、滨田文雄博士（名誉主席）、柴山敦博士（秋田大学，总主席）和Mitsutoshi Jikei和Takeshi Gotoh博士（秋田大学，包含仿生学和生物灵感概念的生物学的优雅特征是分子在纳米尺度上自组装成功能系统。尽管如此，生物灵感通常被解释为提供一些类似生物的特征，可用于指导材料合成为功能性设备和过程。然后，其结果是生物技术系统的发展，越来越多地基于纳米技术工艺的应用，以创造更小的物体。然而，这种解释忽略了一个重要的概念，即生物学利用分子的自组装来创造优雅的纳米结构系统。这种生物纳米结构系统的中心特征是磷脂双层膜的组装，其既提供隔室（即生物细胞）以使复杂生物体（例如植物、动物）的整体功能合理化，又提供稳定蛋白质以辅助生物细胞的感测和致动功能的环境。
Our efforts to build devices that integrate and interact intimately with biology have led to concepts such as “biofabrication” and “4D printing,” exhibiting the desire to mimic nature and indeed incorporate natural products into structures that provide enhanced function, especially in their ability to interact with, signal with, or even communicate with biology. In this special issue of Biotechnology Journal, we invited several leading scholars to provide articles that describe efforts to exploit biological materials for assembly, and to harness or mimic biological assembly processes to build components and systems of advanced function. This issue is an outgrowth of the stimulating meeting held in Akita Japan in the fall of 2017:“The 8th International Conference on Materials Engineering for Resources” hosted by Drs. Kazuo Otsuka, Yoshio Nagai, Noboru Yoshimura, and Fumio Hamada (honorary chairpersons), Dr. Atsushi Shibayama (Akita U., General Chairperson), and Drs. Mitsutoshi Jikei and Takeshi Gotoh (Akita U., Executive committee).The elegant feature of biology that encapsulates the concepts of biomimetics and bioinspiration is the selfassembly of molecules into functional systems at the dimensions of nanometers. Nonetheless, bioinspiration is usually interpreted as providing some biological-like characteristics that can be used to guide the synthesis of materials into functional devices and processes. Then, the result is the development of biotechnology systems that are based increasingly on the application of nanotechnology processes to create smaller objects. However, that interpretation overlooks the important concept that biology utilizes self-assembly of molecules to create elegant nanostructured systems. A central feature of such biological nanostructured systems is the assembly of phospholipid bilayer membranes that both provide compartments (ie, biological cells) to rationalize the overall function of complex organisms (eg, plants, animals) and also to provide an environment in which to stabilize proteins to assist in the sensing and actuating functions of biological cells.