The expression of cancerous inhibitor protein phosphatase 2A in chronic rhinosinusitis with nasal polyps
The expression of cancerous inhibitor protein phosphatase 2A in chronic rhinosinusitis with nasal polyps
复制标题
DOI：
10.1080/00016489.2016.1195918
复制
发表时间：
2016-06
影响因子：
1.4
通讯作者：
E. Terna;A. Luukkainen;M. Seppälä;R. Renkonen;H. Huhtala;S. Tommola;T. Paavonen;P. Kauppi;O. Tynninen;L. Jeskanen;S. Toppila-Salmi
中科院分区：
文献类型：
--
作者：
E. Terna;A. Luukkainen;M. Seppälä;R. Renkonen;H. Huhtala;S. Tommola;T. Paavonen;P. Kauppi;O. Tynninen;L. Jeskanen;S. Toppila-Salmi
摘要结论：慢性鼻窦炎合并鼻息肉合并阿司匹林加重呼吸系统疾病(CRSwNP+AERD)与癌基因蛋白磷酸酶抑制物(CIP2A)表达和嗜酸性粒细胞增多有关。需要进行更大样本量的进一步研究，以进一步评估CIP2A及其相关通路在CRSwNP+AERD中的作用。目的：前列腺素E_2水平降低可能与CRSwNP+AERD和c-Myc水平降低有关。这项研究的目的是评估癌蛋白CIP2A，另一种c-Myc调节剂，在伴/不伴AERD的CRSwNP和前鼻孔息肉中的表达和修订预测作用。方法：对90例CRSwNP或ACP患者鼻息肉组织标本进行回顾性分析，评价鼻息肉黏膜嗜酸性粒细胞增多症。在这些人群中，90例鼻息肉标本可用于多克隆抗CIP2A抗体的免疫组织化学染色，19例对照鼻黏膜标本。CIP2A染色强度和组织嗜酸性粒细胞由两名盲人在光学显微镜下进行评估。90名患者和19名对照的受试者特征来自患者记录，另外还通过对照的问卷获得。随访数据来自84名患者和16名对照的患者记录。结果：正常下鼻甲黏膜和鼻息肉组织中均有上皮性CIP2A的表达。CRSwNP+AERD组的表达显著低于对照组和CRSwNP非AERD组(p<0.05)，而既往手术、过敏性鼻炎和皮质类固醇的使用确实预示了翻修手术的需要(p<；0.05)。
Abstract Conclusion: The study suggests that cancerous inhibitor of protein phosphatase 2A (CIP2A) expression and eosinophilia associate with chronic rhinosinusitis with nasal polyps with aspirin exacerbated respiratory disease (CRSwNP + AERD). Further studies with a larger sample size are needed to evaluate further the role of CIP2A and related pathways in CRSwNP + AERD. Objectives: Low prostaglandin E2 levels putatively associate with CRSwNP + AERD and decreased c-Myc levels. The aim of this study was to evaluate the expression and revision-predictive role of oncoprotein CIP2A, another c-Myc modulator, in CRSwNP with/without AERD, and in antrochoanal polyps. Method: Ninety retrospective archival objective glasses of nasal polyp tissue from CRSwNP or ACP patients were used for assessing mucosal eosinophilia. Of this population, 90 archival nasal polyp specimens were available for immunohistochemical staining with a polyclonal anti-CIP2A antibody, together with 19 control nasal mucosa specimens. CIP2A staining intensity and tissue eosinophilia were assessed by two blinded observers with a light microscope. Subject characteristics from 90 patients and 19 controls were obtained from patient records and additionally by a questionnaire from controls. The follow-up data was available from patient records of 84 patients and 16 controls. Results: The expression of epithelial CIP2A was detected both in control inferior turbinate mucosa and nasal polyps. The expression was significantly lower in the CRSwNP + AERD group compared to controls and CRSwNP without AERD (p 0.05), whereas previous surgery, allergic rhinitis, and use of corticosteroids did predict the need for revision surgery (p < 0.05).