Implications of dynamic patterns of Delta and Notch expression for cellular interactions during Drosophila development.
Implications of dynamic patterns of Delta and Notch expression for cellular interactions during Drosophila development.
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发表时间：
1993-02
期刊：
影响因子：
4.6
通讯作者：
P. J. Kooh;R. Fehon;M. Muskavitch
中科院分区：
文献类型：
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作者：
P. J. Kooh;R. Fehon;M. Muskavitch
在胚胎和胚胎后果蝇发育的许多组织中，Delta和Notch功能是决定细胞命运的必要条件。Delta由相互作用的细胞群的所有成员表达，其中命运被指定，随后随着细胞稳定地采用特定的命运而下调。许多胚层衍生物的多相表达意味着在许多组织中对δ函数有连续的要求。在细胞水平上，Delta和Notch在发育组织中的表达通常是一致的。在亚细胞水平上，Delta和Notch在相互作用细胞表面的下调过程中定位于明显的内吞囊泡中，这表明它们在细胞发育过程中作为信号和受体的相互作用是一致的。
Delta and Notch function are required for cell fate specification in numerous tissues during embryonic and postembryonic Drosophila development. Delta is expressed by all members of interacting cell populations within which fates are being specified and is subsequently down-regulated as cells stably adopt particular fates. Multiphasic expression in the derivatives of many germ layers implies successive requirements for Delta function in a number of tissues. At the cellular level, Delta and Notch expression are generally coincident within developing tissues. At the subcellular level, Delta and Notch are localized in apparent endocytic vesicles during down-regulation from the surfaces of interacting cells, implying an interaction consistent with their proposed roles as signal and receptor in cellular interactions during development.