Adhesive receptors on malaria-parasitized red cells
Adhesive receptors on malaria-parasitized red cells
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DOI：
10.1053/beha.1999.0051
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发表时间：
1999-12-01
影响因子：
2.1
通讯作者：
Baruch, DI
中科院分区：
文献类型：
--
作者：
Baruch, DI
抗原变异、重置和细胞粘附是恶性疟原虫存活和毒力的关键决定因素。这些特性存在于称为恶性疟原虫红细胞膜蛋白1（PfEMP 1）的多基因蛋白质家族中，该蛋白质家族由大而多样的var基因家族编码。PfEMP 1在恶性疟原虫的生物学及其与人类宿主的相互作用中起着重要作用。参与细胞粘附、重置和抗原变异的分子机制和结构域开始展现。介导重置和粘附到几个关键的宿主受体的结构域已经被确定。了解PfEMP 1在疟原虫发病和存活中的作用是开发抗粘附疫苗和治疗药物以降低恶性疟原虫感染的死亡率和发病率的关键。
Antigenic variation, resetting and cytoadhesion are key determinants in the survival and virulence of the malaria parasite Plasmodium falciparum. These properties reside in a multigene protein family called P. falciparum erythrocyte membrane protein 1 (PfEMP1), encoded by the large and diverse var gene family. PfEMP1 plays a central role in the biology of P. falciparum and its interaction with the human host. The molecular mechanism and the domains involved in cytoadherence, resetting and antigenic variation are beginning to unfold. Domains mediating resetting and adhesion to several key host receptors have already been identified. Understanding the role of PfEMP1 in the pathogenesis and survival of malaria parasites is the key for the development of anti-adhesion vaccines and therapeutics to reduce the mortality and morbidity of P. falciparum infections.