REGENERATION, DUPLICATION AND TRANSDETERMINATION IN FRAGMENTS OF LEG DISC OF DROSOPHILA-MELANOGASTER
REGENERATION, DUPLICATION AND TRANSDETERMINATION IN FRAGMENTS OF LEG DISC OF DROSOPHILA-MELANOGASTER
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DOI：
10.1016/0012-1606(71)90127-8
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发表时间：
1971-01-01
影响因子：
2.7
通讯作者：
SCHUBIGER, G
中科院分区：
文献类型：
--
作者：
SCHUBIGER, G
当前腿盘的碎片被注射到老的幼虫寄主体内时，它们根据器官计划分化出不同的结构。当允许短暂的额外生长时间时，它们还可以复制模式、再生或形成标记单位的多个副本。只有当片段培养较长时间时，才会观察到重定。所产生的分化类型取决于片段的起源。中间的半部分再生，表现出单位的倍增，后来非常频繁地重新确定；模式重复是罕见的。在相同的条件下，侧半不形成同型结构，但往往重复其模式。再生发生在近远端以及中外侧方向。研究表明，椎间盘的特定四分之一能够再生出一条完整的腿。构造似乎主要由一个切割区依次取代。
When fragments of the foreleg disc are injected into old larval hosts, they differentiate structures according to the anlage plan. When a short additional time for growth is allowed, they can also duplicate patterns, regenerate, or form multiple copies of units of markers. Transdetermination is observed only when fragments are cultured for longer periods.The type of differentiation which is produced is dependent on the origin of the fragment. Medial halves regenerate, show multiplication of units, and later on transdetermine very frequently; pattern duplications are rare. Under the same conditions, lateral halves do not form allotypic structures but often duplicate their patterns.Regeneration occurs in a proximodistal as well as a mediolateral direction. It was shown that a specific quarter of a disc is capable of regenerating a complete leg.It seems that structures are successively replaced predominantly from one cutting region.