Dragon (repulsive guidance molecule b, RGMb) is a novel gene that promotes colorectal cancer growth.
Dragon (repulsive guidance molecule b, RGMb) is a novel gene that promotes colorectal cancer growth.
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Dragon（排斥引导分子b，RGMb）是一种促进结直肠癌生长的新型基因。
DOI：
10.18632/oncotarget.4110
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发表时间：
2015-08-21
期刊：
影响因子：
--
通讯作者：
Guleng B
中科院分区：
文献类型：
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作者：
Shi Y;Chen GB;Huang XX;Xiao CX;Wang HH;Li YS;Zhang JF;Li S;Xia Y;Ren JL;Guleng B
结直肠癌（CRC）是最常见的癌症之一，也是癌症死亡的主要原因。然而，CRC的发生、生长和转移的分子机制尚不清楚。Dragon（RGMb）是排斥性导向分子（RGM）家族的一员，最近被鉴定为骨形态发生蛋白（BMP）信号传导的共受体，但Dragon在CRC发展中的作用尚不明确。在这里，我们表明，与CAC小鼠模型和人类患者的对照组织相比，Dragon在结肠癌组织中的表达增加。Dragon促进CT26.WT和CMT 93结肠癌细胞的增殖，并加速异种移植小鼠模型中的肿瘤生长。Dragon对结肠癌发展的作用是通过BMP 4-Smad 1/5/8和Erk 1/2途径介导的。因此，我们的研究结果表明，Dragon是一种通过BMP途径促进CRC生长的新基因。Dragon有可能成为大肠癌潜在的治疗靶点。
Colorectal cancer (CRC) is one of the most commonly diagnosed cancers and a major cause of cancer death. However, the molecular mechanisms underlying CRC initiation, growth and metastasis are poorly understood. Dragon (RGMb), a member of the repulsive guidance molecule (RGM) family, has been recently identified as a co-receptor for bone morphogenetic protein (BMP) signaling, but the role of Dragon in CRC development is undefined. Here, we show that Dragon expression was increased in colon cancer tissues compared to control tissues in CAC mouse model and in human patients. Dragon promoted proliferation of CT26.WT and CMT93 colon cancer cells and accelerated tumor growth in the xenograft mouse model. Dragon's action on colon cancer development was mediated via the BMP4-Smad1/5/8 and Erk1/2 pathways. Therefore, our results have revealed that Dragon is a novel gene that promotes CRC growth through the BMP pathway. Dragon may be exploited as a potential therapeutic target for CRC treatment.