Predeliberation activity in prefrontal cortex and striatum and the prediction of subsequent value judgment.
Predeliberation activity in prefrontal cortex and striatum and the prediction of subsequent value judgment.
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DOI：
10.3389/fnins.2013.00225
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发表时间：
2013
影响因子：
4.3
通讯作者：
Koch C
中科院分区：
文献类型：
--
作者：
Maoz U;Rutishauser U;Kim S;Cai X;Lee D;Koch C
理性的、基于价值的决策要求在适当的考虑之后选择具有最高主观期望值的选项。我们研究了猴子的背外侧前额叶皮层（DLPFC）和纹状体的活动，它们在较小的、立即的奖励和较大的、延迟的奖励之间做出决定。我们以前发现神经元，根据动物的选择，在这个任务中调制他们的活动，而它审议（选择神经元）。在这里，我们发现了神经元，它们的尖峰活动可以预测所选目标的空间位置（空间偏置神经元）或所选奖励的大小（奖励偏置神经元），这是在提示我们做出选择之前，也就是在理性思考开始之前。随着动物与两种决策选择相关的价值变得更加相似，它们的预测能力也会增加。腹侧纹状体（VS）优先含有空间偏置神经元;尾状核（CD）优先含有选择神经元。相反，DLPFC包含了大量的所有三种神经元类型，但选择神经元并不优先也偏置神经元的任何一种，也没有空间偏置神经元优先也选择神经元，反之亦然。我们提出了一个简单的赢家通吃（WTA）电路模型来解释选择和偏见神经元的分离。该模型再现了我们的结果，并做出了更多的预测，这些预测得到了经验的证实。我们的数据是兼容的假设，即DLPFC和纹状体港口解离的神经群体，代表选择和审议前的偏见，结合后，线索发病;偏见神经元有一个较弱的影响，最终决定比选择神经元，所以他们的影响是逐步明显的试验中，与决策方案的价值越来越相似。
Rational, value-based decision-making mandates selecting the option with highest subjective expected value after appropriate deliberation. We examined activity in the dorsolateral prefrontal cortex (DLPFC) and striatum of monkeys deciding between smaller, immediate rewards and larger, delayed ones. We previously found neurons that modulated their activity in this task according to the animal's choice, while it deliberated (choice neurons). Here we found neurons whose spiking activities were predictive of the spatial location of the selected target (spatial-bias neurons) or the size of the chosen reward (reward-bias neurons) before the onset of the cue presenting the decision-alternatives, and thus before rational deliberation could begin. Their predictive power increased as the values the animals associated with the two decision alternatives became more similar. The ventral striatum (VS) preferentially contained spatial-bias neurons; the caudate nucleus (CD) preferentially contained choice neurons. In contrast, the DLPFC contained significant numbers of all three neuron types, but choice neurons were not preferentially also bias neurons of either kind there, nor were spatial-bias neurons preferentially also choice neurons, and vice versa. We suggest a simple winner-take-all (WTA) circuit model to account for the dissociation of choice and bias neurons. The model reproduced our results and made additional predictions that were borne out empirically. Our data are compatible with the hypothesis that the DLPFC and striatum harbor dissociated neural populations that represent choices and predeliberation biases that are combined after cue onset; the bias neurons have a weaker effect on the ultimate decision than the choice neurons, so their influence is progressively apparent for trials where the values associated with the decision alternatives are increasingly similar.
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影响因子：
16.2
作者：
Fried, Itzhak;Mukamel, Roy;Kreiman, Gabriel
通讯作者：
Kreiman, Gabriel
影响因子：
2.5
作者：
Kable, Joseph W.;Glimcher, Paul W.
通讯作者：
Glimcher, Paul W.
DOI：
10.1111/j.1749-6632.2011.05994.x
发表时间：
2011-01-01
期刊：
YEAR IN COGNITIVE NEUROSCIENCE
影响因子：
--
作者：
Haynes, John-Dylan
通讯作者：
Haynes, John-Dylan
影响因子：
9.2
作者：
Haynes, John-Dylan;Sakai, Katsuyuki;Passingham, Richard E.
通讯作者：
Passingham, Richard E.
影响因子：
3.7
作者：
Bode S;He AH;Soon CS;Trampel R;Turner R;Haynes JD
通讯作者：
Haynes JD