Development of Type 2 Innate Lymphoid Cells Is Selectively Inhibited by Sustained E Protein Activity.
Development of Type 2 Innate Lymphoid Cells Is Selectively Inhibited by Sustained E Protein Activity.
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DOI：
10.4049/immunohorizons.1900045
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发表时间：
2019-12-18
期刊：
影响因子：
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通讯作者：
Alberola-Ila, Jose
中科院分区：
文献类型：
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作者：
Berrett, Hannah;Qian, Liangyue;Alberola-Ila, Jose
先天淋巴样细胞（ILCs）是组织内的淋巴样细胞，主要存在于屏障表面并参与对病原体的初始反应。它们根据基于细胞因子产生和转录因子表达的效应程序被分为不同的类型。它们都起源于共同的淋巴细胞前体，但调节ILC亚群发育的分子机制尚不清楚。先前使用Id2敲除小鼠进行的实验表明，E蛋白活性抑制是所有ILC亚群发育的绝对必要条件。在这项研究中，我们使用遗传方法来证明，在ILC发育过程中，E蛋白活性的小幅增加选择性地抑制了2型ILC的发育。1型ILC大多不受干扰，而3型ILC仅表现出轻微的抑制。这种效应在ILC2祖细胞阶段首先明显，并且是ILC固有的。因此，我们的研究结果表明，E蛋白活性的调节可以影响ILCs发育过程中细胞命运的决定。
Innate lymphoid cells (ILCs) are tissue-resident lymphoid cells that reside mostly at barrier surfaces and participate in the initial response against pathogens. They are classified into different types based on effector programs that are based on cytokine production and transcription factor expression. They all derive from the common lymphoid precursor, but the molecular mechanisms regulating ILC subset development is not well understood. Experiments using Id2 knockout mice have previously shown that E protein activity inhibition is an absolute requirement for the development of all ILC subsets. In this study, we use a genetic approach to demonstrate that small increases in E protein activity during ILC development selectively inhibit type 2 ILC development. Type 1 ILCs are mostly unperturbed, and type 3 ILC show only a minor inhibition. This effect is first evident at the ILC2 progenitor stage and is ILC intrinsic. Therefore, our results demonstrate that modulation of E protein activity can bias cell fate decisions in developing ILCs.