A brain in flame; do inflammasomes and pyroptosis influence stroke pathology?
A brain in flame; do inflammasomes and pyroptosis influence stroke pathology?
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DOI：
10.1111/bpa.12476
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发表时间：
2017-03-01
期刊：
影响因子：
6.4
通讯作者：
Allan, Stuart M.
中科院分区：
文献类型：
--
作者：
Barrington, Jack;Lemarchand, Eloise;Allan, Stuart M.
中风是全世界导致死亡和残疾的主要原因之一。炎症在中风的整个过程中起着关键作用，从发病到几天到几个月后的损伤后修复阶段。几个调节分子与炎症有关，但急性脑损伤最确定的炎症介质是细胞因子白介素1。白介素1由称为炎性小体的大分子复合体调节，这些大分子复合体在细胞因子释放和细胞死亡中发挥核心作用。在这篇综述中，我们重点介绍了炎性小体研究的最新进展，并提出了炎性小体成分在卒中损害进展中的关键作用。
Stroke is one of the leading causes of death and disability worldwide. Inflammation plays a key role across the time course of stroke, from onset to the post-injury reparative phase days to months later. Several regulatory molecules are implicated in inflammation, but the most established inflammatory mediator of acute brain injury is the cytokine interleukin-1. Interleukin-1 is regulated by large, macromolecular complexes called inflammasomes, which play a central role in cytokine release and cell death. In this review we highlight recent advances in inflammasome research and propose key roles for inflammasome components in the progression of stroke damage.