A GLYCOPROTEIN ANTIGEN OF SCHISTOSOMA-MANSONI EXPRESSED ON THE GYNECOPHORAL CANAL OF MATURE MALE WORMS
A GLYCOPROTEIN ANTIGEN OF SCHISTOSOMA-MANSONI EXPRESSED ON THE GYNECOPHORAL CANAL OF MATURE MALE WORMS
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DOI：
10.4269/ajtmh.1985.34.508
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发表时间：
1985-01-01
影响因子：
3.3
通讯作者：
STRAND, M
中科院分区：
文献类型：
--
作者：
ARONSTEIN, WS;STRAND, M
通过使用针对尾蚴糖蛋白制备的单克隆抗体，对曼氏链霉菌卵、尾蚴以及雄性和雌性蠕虫表达的表观分子量为 80,000 的糖蛋白抗原进行了表征。该抗原在雄性和雌性蠕虫的表面都有表达。然而，它在雄性表面的表达仅限于源自完全专利感染的雄性线虫的雌蕊管。这种表面表达模式表明在血吸虫有性繁殖中发挥作用。
A glycoprotein antigen of 80,000 apparent MW expressed by S. mansoni eggs, cercariae and male and female worms was characterized by use of a monoclonal antibody prepared against cercarial glycoproteins. The antigen was expressed on the surface of both male and female worms. Its expression on the male surface, however was restricted to the gynecophoral canal of male worms derived from fully patent infections. This pattern of surface expression suggests a role in schistosome sexual reproduction.