Staging liver fibrosis with DWI: is there an added value for diffusion kurtosis imaging?
Staging liver fibrosis with DWI: is there an added value for diffusion kurtosis imaging?
复制标题
用 DWI 对肝纤维化进行分期：弥散峰度成像有附加价值吗？
DOI：
10.1007/s00330-017-5245-6
复制
发表时间：
2018-07-01
影响因子：
5.9
通讯作者：
Zeng, Mengsu
中科院分区：
文献类型：
--
作者：
Yang, Li;Rao, Shengxiang;Zeng, Mengsu
ObjectivesTo assess liver fibrosis in patients with chronic liver disease using diffusion kurtosis imaging (DKI) in comparison with conventional diffusion-weighted imaging, with histology as reference standard.MethodsThis prospective study included 81 patients and DKI with b-values of 0, 200, 500, 1,000, 1,500, 2,000 s/mm2were performed. Mean diffusivity (MD), mean kurtosis (MK) and apparent diffusion coefficient (ADC) maps were calculated. The diagnostic efficacy of MD, MK and ADC for predicting stage 2 fibrosis or greater, and stage 3 fibrosis or greater were compared.ResultsThe MD (rho=-0.491,p<0.001), MK (rho=0.537,p<0.001) and ADC (rho=-0.496,p<0.001) correlated significantly with fibrosis stages, and ADC exhibited a strong negative correlation with MK (rho=-0.968;p<0.001) and a moderate association with MD (rho=0.601,p<0.001). Areas under the curves (AUCs) for predicting stage 2 fibrosis or greater were not significantly different (p>0.05) between MK (0.809) and ADC (0.797) as well as between MD (0.715) and ADC. AUCs were also similar for MD (0.710), MK (0.768) and ADC (0.747) for predicting stage 3 fibrosis or greater.ConclusionAlthough DKI is feasible for predicting liver fibrosis in patients with chronic liver disease, MD and MK offer similar diagnostic performance to ADC values.Key Points•Diffusion kurtosis imaging is feasible for staging liver fibrosis.•Diffusion kurtosis and monoexponential model are highly correlated.•The kurtosis model offers no added value to the conventional, monoexponential model
