Population-based epidemiological study of primary intracranial tumors in childhood
Population-based epidemiological study of primary intracranial tumors in childhood
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DOI：
10.1007/s00381-010-1126-x
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发表时间：
2010-08-01
影响因子：
1.4
通讯作者：
Kuratsu, Jun-ichi
中科院分区：
文献类型：
--
作者：
Makino, Keishi;Nakamura, Hideo;Kuratsu, Jun-ichi
脑肿瘤是儿童最常见的实体肿瘤，预后较差。来自以人群为基础的癌症登记的流行病学数据提供了确定儿童脑瘤发病率所必需的信息。为了解日本熊本县儿童原发颅内肿瘤的流行病学，对至2008年间确诊的210例15岁以下儿童原发颅内肿瘤进行了调查，其中159例(75.7%)经手术证实，年龄调整后年发病率为36.1/百万儿童。男孩和女孩的比率为1.31。0至4岁、5至9岁和10至14岁年龄组的年发病率分别为28.5、40.9和38.4例/百万。发病率最高的是10至14岁的男孩(53.6‰)，最低的是10至14岁的女孩(22.6‰)。最常见的肿瘤是星形细胞瘤(35.7%)，年发病率为13.2/百万，其次是生殖细胞瘤(14.3%，5.0/百万)、颅咽管瘤(10.5%，3.8/百万)、髓母细胞瘤(10.0%，3.7/百万)和室管膜瘤(4.8%，1.5/百万)。肿瘤类型的分布随年龄和性别的不同而不同。虽然在0到4岁的男孩中没有生殖细胞肿瘤，但在10到14岁的男孩中，它们是第二常见的肿瘤。相反，10到14岁的女孩中没有髓母细胞瘤，而0到4岁的女孩中髓母细胞瘤的发病率很高。在这次熊本调查中，儿童原发性颅内肿瘤的发病率与西方国家相似。然而，特定组织类型的脑肿瘤，如生殖细胞肿瘤和颅咽管瘤，在日本和西方国家的发病率和相对频率不同。
Brain tumors are the most common solid tumors in children and their prognosis is poor. Epidemiologic data from a population-based cancer registry provide the information necessary to determine the incidence rate of pediatric brain tumors. The aim of this study was to determine the epidemiology of childhood primary intracranial tumors in Kumamoto Prefecture, Japan.We surveyed 210 patients younger than 15 years who were diagnosed with primary intracranial tumors between 1989 and 2008; 159 (75.7%) of the tumors were confirmed microscopically.The age-adjusted annual incidence rate was 36.1 cases per million children. The boys/girls ratio was 1.31. The age-specific annual incidence rate was 28.5-, 40.9-, and 38.4 cases per million for the 0- to 4-, 5- to 9-, and 10- to 14-year age group, respectively. The incidence was highest in 10- to 14-year-old boys (53.6 per million) and lowest in 10- to 14-year-old girls (22.6 per million). The most common tumor was astrocytoma (35.7%) with an annual incidence rate of 13.2 per million, followed by germ cell tumor (14.3%, 5.0 per million), craniopharyngioma (10.5%, 3.8 per million), medulloblastoma (10.0%, 3.7 per million), and ependymoma (4.8%, 1.5 per million). The distribution of the tumor type varied with the patient age and gender. Although there were no germ cell tumors in 0- to 4-year-old boys, they were the second-most common tumor in 10- to 14-year-old boys. Conversely, while there were no medulloblastomas in 10- to 14-year-old girls, their incidence was high in 0- to 4-year-old girls.In this Kumamoto survey, the incidence rate of primary intracranial tumors in children was similar to that in Western countries. However, the incidence and relative frequency of particular histological types of childhood brain tumors such as germ cell tumors and craniopharyngiomas were different between Japan and Western countries.