A functional varient in microRNA-146a is associated with risk of esophageal squamous cell carcinoma in Chinese Han
A functional varient in microRNA-146a is associated with risk of esophageal squamous cell carcinoma in Chinese Han
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microRNA-146a 的功能变异与中国汉族食管鳞状细胞癌的风险相关
DOI：
10.1007/s10689-010-9370-5
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发表时间：
2010-12-01
期刊：
影响因子：
2.2
通讯作者：
Bai, Yun
中科院分区：
文献类型：
--
作者：
Guo, Hong;Wang, Kai;Bai, Yun
microRNA是一类新的非蛋白质编码的小RNA，其功能是肿瘤抑制因子或癌基因。它们参与不同的生物学途径，并作为基因调节剂发挥作用。位于miR-146 a前体序列中的G>C多态性（rs 2910164）导致其茎区从G：U变为C：U。然而，它仍然在很大程度上是未知的，这种单核苷酸多态性（SNP）是否可能改变食管鳞状细胞癌（ESCC）的易感性。在本研究中，我们评估了rs 2910164与ESCC易感性之间的关系，在一项病例对照研究中，444例散发性ESCC患者和468例匹配的无癌对照在中国汉族人群中。与rs 2910164变异基因型CC相比，GG基因型与ESCC风险增加相关（比值比，2.39，95%置信区间，1.36-4.20）。在吸烟者中，rs 2910164 GG基因型的风险更显著（比值比，3.17，95%置信区间，1.71-4.46）。分层分析发现rs 2910164 C/G变异与临床TNM分期有显著相关性（P< 0.01）。这些研究结果表明，前miR-146 a中的这种功能性SNP可能有助于ESCC易感性和临床结果。
MicroRNAs are a new class of non-proteincoding, small RNAs that function as tumor suppressors or oncogenes. They participate in diverse biological pathways and function as gene regulators. A G>C polymorphism (rs2910164), which is located in the sequence of miR-146a precursor, results in a change from G:U to C:U in its stem region. However, it remains largely unknown whether this single nucleotide polymorphism (SNP) may alter esophageal squamous cell carcinoma (ESCC) susceptibility. In the current study, we evaluated association between rs2910164 and ESCC susceptibility in a case–control study of 444 sporadic ESCC patients and 468 matched cancer-free controls in a Chinese Han population. Compared with rs2910164 variant genotype CC, genotype GG was associated with increased risk of ESCC (Odds Ratio, 2.39, 95% Confidence Interval, 1.36–4.20). In the smokers, the risk of rs2910164 GG genotype was more notable (Odds Ratio, 3.17, 95% Confidence Interval, 1.71–4.46). In the stratification analyses, we also found there was a strong correlation between rs2910164 C/G variant and the clinical TNM stage (P< 0.01). These findings suggest that this functional SNP in pre-miR-146a could contribute to ESCC susceptibility and clinical outcome.