An expeditious synthesis of DPD and boron binding studies
An expeditious synthesis of DPD and boron binding studies
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DOI：
10.1021/ol047695j
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发表时间：
2005-02-17
期刊：
影响因子：
5.2
通讯作者：
Bassler, BL
中科院分区：
文献类型：
--
作者：
Semmelhack, MF;Campagna, SR;Bassler, BL
DPD（4，5-dihydroxypentane-2，3-dione）是一种不稳定的小分子，被认为是细菌群体感应的通用信号物质的来源。该合成允许制备同位素标记的DPD和entDPD，以及详细研究自发结合硼酸盐，得到不寻常的硼酸盐络合物6，海洋细菌如哈氏弧菌的信号。
A practical synthesis has been developed for DPD (4,5-dihydroxypentane-2,3-dione), an unstable small molecule that is proposed to be the source of universal signaling agents for quorum sensing in bacteria. The synthesis allows preparation of isotopically labeled DPD and entDPD as well as detailed studies of spontaneous binding to borate to give the unusual borate complex 6, the signal for marine bacteria such as Vibrio harveyi.