Interleukin-32 in inflammatory autoimmune diseases.
Interleukin-32 in inflammatory autoimmune diseases.
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DOI：
10.4110/in.2014.14.3.123
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发表时间：
2014-06
期刊：
影响因子：
6
通讯作者：
Kim S
中科院分区：
文献类型：
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作者：
Kim S
白细胞介素-32 (IL-32) 是一种诱导重要炎症细胞因子的细胞因子，例如肿瘤坏死因子-α (TNFα) 和 IL-6，其表达在各种炎症性自身免疫性疾病、某些癌症以及病毒感染中升高。 IL-32基因首先从活化的T细胞中克隆出来，但在其他免疫细胞和非免疫细胞中也发现了IL-32表达。 IL-32 基因在除啮齿类动物外的大多数哺乳动物中均已发现。在每种亚型不存在特定活性的情况下，它被转录为多剪接变体。 IL-32主要在感染、自身免疫、癌症、血管疾病和肺部疾病等临床领域进行研究。由于小鼠体内缺乏IL-32基因，因此很难研究IL-32在体内的精确作用。尽管IL-32新细胞因子作为免疫调节分子在自身免疫、感染和癌症中发挥重要作用而受到关注，但小鼠IL-32基因的缺乏限制了体内研究并限制了IL-32研究在临床应用中的进一步发展。在这篇综述中，我们讨论了 IL-32 在炎症性肠病和类风湿性关节炎中的调节和功能。
Interleukin-32 (IL-32) is a cytokine inducing crucial inflammatory cytokines such as tumor necrosis factor-α (TNFα) and IL-6 and its expression is elevated in various inflammatory autoimmune diseases, certain cancers, as well as viral infections. IL-32 gene was first cloned from activated T cells, however IL-32 expression was also found in other immune cells and non-immune cells. IL-32 gene was identified in most mammals except rodents. It is transcribed as multiple-spliced variants in the absence of a specific activity of each isoform. IL-32 has been studied mostly in clinical fields such as infection, autoimmune, cancer, vascular disease, and pulmonary diseases. It is difficult to investigate the precise role of IL-32 in vivo due to the absence of IL-32 gene in mouse. The lack of mouse IL-32 gene restricts in vivo studies and restrains further development of IL-32 research in clinical applications although IL-32 new cytokine getting a spotlight as an immune regulatory molecule processing important roles in autoimmune, infection, and cancer. In this review, we discuss the regulation and function of IL-32 in inflammatory bowel diseases and rheumatoid arthritis.