Acute third ventricular administration of insulin decreases food intake in two paradigms
Acute third ventricular administration of insulin decreases food intake in two paradigms
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DOI：
10.1016/s0091-3057(01)00780-8
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发表时间：
2002-05-01
影响因子：
3.6
通讯作者：
Woods, SC
中科院分区：
文献类型：
--
作者：
Air, EL;Benoit, SC;Woods, SC
胰腺激素胰岛素被认为是食物摄入的重要调节因子。与这一假设相一致的是，外源性胰岛素在不影响血糖的剂量下可靠地抑制食物摄入和体重。然而，先前的实验已经利用了长期递送范例，其中通过渗透微型泵施用胰岛素，并且在几天内测量体重和食物摄入的变化。在单独的实验中，我们报告说，急性中央注射胰岛素可以减少食物摄入量。在实验1中，将胰岛素（8mU）注射到第三脑室中可靠地抑制了在大鼠的黑暗期开始时颗粒状大鼠食物的摄入。在实验2中，中央胰岛素可靠和剂量依赖性抑制摄入1小时15%蔗糖餐中的中间的光相。这些数据表明，胰岛素可以减少食物摄入的急性交付范例，并提供另一种手段，通过它来评估其他中央系统的作用，在胰岛素的药物治疗的能量稳态的影响。(C)2002年爱思唯尔科技有限公司All rights reserved.
The pancreatic hormone, insulin has been hypothesized to be an important regulator of food intake. Consistent with this hypothesis is the finding that exogenous insulin, in doses that do not affect blood glucose, reliably suppresses food intake and body weight. However, previous experiments have utilized a long-term delivery paradigm, in which insulin is administered via osmotic minipump and changes in body weight and food intake are measured across days. In separate experiments, we report that acute central injections of insulin can reduce food intake. In Experiment 1, injection of insulin (8 mU) into the third cerebral ventricle reliably suppressed intake of pelleted rat chow beginning at onset of the rats' dark phase. In Experiment 2, central insulin reliably and dose dependently suppressed intake of a 1-h 15% sucrose meal in the middle of the light phase. These data suggest that insulin can reduce food intake in acute delivery paradigms and provide another means by which to assess the role of other central systems in the medication of insulin's effects on energy homeostasis. (C) 2002 Elsevier Science Inc. All rights reserved.