ANTIGENIC COMPONENTS OF GROUP-A ARBOVIRUS VIRIONS
ANTIGENIC COMPONENTS OF GROUP-A ARBOVIRUS VIRIONS
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DOI：
10.1128/jvi.12.5.1034-1042.1973
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发表时间：
1973-01-01
影响因子：
5.4
通讯作者：
RUSSELL, PK
中科院分区：
文献类型：
--
作者：
DALRYMPL.JM;VOGEL, SN;RUSSELL, PK
用非离子洗涤剂选择性降解A组虫媒病毒Sindbis(SIN)、西部(WEE)和东部马脑炎(EEE)，生成核心颗粒和可溶性包膜成分。用放射免疫沉淀法进行抗原性分析表明，三种病毒核心颗粒之间的抗原性具有明显的相似性。可溶性包膜组分具有与完整病毒粒子相似的抗原性。SIN和WEE包膜之间有密切的关系，而EEE包膜抗原具有抗原性。这些数据表明，A组虫媒病毒的核衣壳含有该组共同的抗原决定簇；包膜包含病毒特异性抗原以及与亚组成员相关的抗原。
Three group A arboviruses, Sindbis (SIN), western (WEE) and eastern equine encephalitis (EEE), were selectively degraded with a nonionic detergent to yield a core particle and a soluble envelope component. Antigenic analysis by using radioimmune precipitation techniques revealed marked antigenic similarity among the core particles of the three viruses. The soluble envelope component exhibited antigenic specificity similar to that of intact virions. A close relationship between SIN and WEE envelopes was shown, whereas EEE envelope antigen appeared antigenically specific. These data indicate that nucleocapsids of group A arboviruses contain an antigenic determinant common to the group; the envelope contains virus-specific antigens as well as antigens which relate members of a subgroup.