A FAMILY OF POTASSIUM CHANNEL GENES RELATED TO EAG IN DROSOPHILA AND MAMMALS
A FAMILY OF POTASSIUM CHANNEL GENES RELATED TO EAG IN DROSOPHILA AND MAMMALS
复制标题
DOI：
10.1073/pnas.91.8.3438
复制
发表时间：
1994-04-12
影响因子：
11.1
通讯作者：
GANETZKY, B
中科院分区：
文献类型：
--
作者：
WARMKE, JW;GANETZKY, B
我们已经确定了一个保守的基因家族与果蝇eag，它编码一个独特的类型的电压激活的K+通道。从果蝇、小鼠和人组织的cDNA文库筛选中回收了三个相关基因。其中一个基因是小鼠eag的对应基因，另外两个代表另外的亚家族。人类基因定位在7号染色体上。家族成员在其疏水核心中共享至少47%的氨基酸同一性，并且都含有与环核苷酸结合结构域同源的区段。序列比较表明，该家族的成员与脊椎动物环核苷酸门控阳离子通道和植物内向整流钾离子通道关系最为密切。另一个K+通道结构基因家族的存在进一步扩展了已知的K+通道的多样性，并对电压敏感离子通道超家族的结构、功能和进化具有重要意义。
We have identified a conserved family of genes related to Drosophila eag, which encodes a distinct type of voltage-activated K+ channel. Three related genes were recovered in screens of cDNA libraries from Drosophila, mouse, and human tissues. One gene is the mouse counterpart of eag; the other two represent additional subfamilies. The human gene maps to chromosome 7. Family members share at least 47% amino acid identity in their hydrophobic cores and all contain a segment homologous to a cyclic nucleotide-binding domain. Sequence comparisons indicate that members of this family are most closely related to vertebrate cyclic nucleotide-gated cation channels and plant inward-rectifying K+ channels. The existence of another family of K+ channel structural genes further extends the known diversity of K+ channels and has important implications for the structure, function, and evolution of the superfamily of voltage-sensitive ion channels.