T1653 mutation in the box a increases the risk of hepatocellular carcinoma in patients with chronic hepatitis B virus genotype C infection
T1653 mutation in the box a increases the risk of hepatocellular carcinoma in patients with chronic hepatitis B virus genotype C infection
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DOI：
10.1086/498522
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发表时间：
2006-01-01
影响因子：
11.8
通讯作者：
Mizokami, M
中科院分区：
文献类型：
--
作者：
Ito, K;Tanaka, Y;Mizokami, M
背景。大多数慢性乙型肝炎病毒感染患者在乙型肝炎e抗原血清转换后成为失活病毒携带者；然而，有一部分患者的转氨酶水平持续异常，并在血清转化后发展为肝细胞癌。方法。在一项年龄匹配的病例对照研究中，40名灭活病毒携带者（平均年龄+/-标准差[SD]，50.9+/-11.1岁）、40名慢性肝炎患者（平均年龄50.2+/-8.9岁）和40名肝细胞癌患者（平均年龄+/-SD，50.7+/-9.4岁）感染了乙型肝炎病毒 对基因型 C 且乙型肝炎 e 抗原抗体检测结果呈阳性的患者进行了分析。结果。肝细胞癌患者中 α 盒中 T1653 的患病率显着高于未患肝细胞癌的灭活病毒携带者（70% vs. 25%；P= 37 U/L，血小板计数为
Background. Most patients with chronic hepatitis B virus infection become carriers of inactive virus after hepatitis B e antigen seroconversion; however, a subgroup of patients have persistent abnormal transaminase levels and develop hepatocellular carcinoma after seroconversion.Methods. In an age-matched case-control study, 40 carriers of inactive virus (mean age +/- standard deviation [SD], 50.9 +/- 11.1 years), 40 patients with chronic hepatitis (mean age 50.2 +/- 8.9 years), and 40 patients with hepatocellular carcinoma (mean age +/- SD, 50.7 +/- 9.4 years) who were infected with hepatitis B virus genotype C and had test results positive for antibody to hepatitis B e antigen were analyzed.Results. The prevalence of T1653 in the box alpha was significantly higher among patients with hepatocellular carcinoma than among carriers of inactive virus who did not have hepatocellular carcinoma (70% vs. 25%; P= 37 U/L, and a platelet count of